NEK7 and EML4

Number of citations of the paper that reports this interaction (PubMedID 31409757)
5

Data Source:
BioGRID (enzymatic study)

		NEK7	EML4
Description		NIMA related kinase 7	EMAP like 4
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GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Microtubule Organizing Center Microtubule	Cytoplasm Microtubule Organizing Center Cytosol Microtubule Membrane Midbody Mitotic Spindle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Molecular_function Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Protein Phosphorylation Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Via Telomerase Spindle Assembly Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Capping	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Mitotic Metaphase Plate Congression Attachment Of Spindle Microtubules To Kinetochore Cell Division
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	EML4 and NUDC in mitotic spindle formation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Height ( 28552196) High altitude adaptation ( 28373541) Pulse pressure ( 33230300)	Chronic obstructive pulmonary disease ( 30804561) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 30061609) Metabolite levels ( 23823483) PR interval ( 32439900) Type 2 diabetes ( 31118516)
Interacting Genes		8 interacting genes: C1orf53 EML4 LYN NEK9 PPP1R13B TERF1 TNNI1 ZBTB41	7 interacting genes: ARIH2 ARL4D MTCH1 NEK6 NEK7 TUBA1B TUBB
Entrez ID		140609	27436
HPRD ID		06027	06310
Ensembl ID		ENSG00000151414	ENSG00000143924
Uniprot IDs		B2R8K8 Q8TDX7	B5MBZ0 Q9HC35
PDB IDs		2WQM 2WQN 5DE2 6NPY 6S73 6S75 6S76	4CGC
Enriched GO Terms of Interacting Partners?
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