PPP1R13B and ARHGAP45

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PPP1R13B	ARHGAP45
Description		protein phosphatase 1 regulatory subunit 13B	Rho GTPase activating protein 45
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Cytosol Membrane Ruffle Membrane Secretory Granule Lumen Azurophil Granule Lumen
	Molecular Function	P53 Binding Protein Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Neuron Death	Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	Neutrophil degranulation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 26426971) General risk tolerance (MTAG) ( 30643258) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglycerides ( 30275531)
Interacting Genes		72 interacting genes: ACSF3 APC ARHGAP45 BFSP2 BRCA1 C2orf42 CAPN7 CBY2 CCDC102B CCDC184 CCHCR1 CDC5L CEP57 CEP63 CGN CKS1B DEUP1 DGCR6L DIRAS1 DTNB FAM184A FAM90A1 GAS2L2 GINS4 GOLGA1 HMG20B HNRNPUL1 KHDRBS1 KHDRBS3 KIF9 KIFC3 KRT20 KRT4 LMNB1 LMNB2 LMO1 LMO3 LNX1 MATN4 MCRS1 MIPOL1 MIS18A MLH1 NAP1L2 NDC80 NEK7 NHSL2 PLEKHA5 PPFIA3 PPP1CA PPP1R18 PRKAB2 PRPH PRR35 RALBP1 RASAL3 RASSF8 SALL1 SOGA1 TCL1A TEKT4 TEX12 TEX9 TNIK TP63 TP73 TRAF1 TSG101 TSGA10 TXLNA ZGPAT ZZZ3	10 interacting genes: BICD2 GMIP GOLGA2 HSF2BP PIBF1 PPP1R13B RINT1 RPL36 TRIM50 ZUP1
Entrez ID		23368	23526
HPRD ID		07345	03097
Ensembl ID		ENSG00000088808	ENSG00000180448
Uniprot IDs		Q96KQ4	B3KVA9 B3KXW7 F5H1R4 K7ES92 K7ES98 Q8IYN3 Q92619
PDB IDs		6HL5	3D25 3FT3
Enriched GO Terms of Interacting Partners?
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