PPP1R13B and PRKAB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PPP1R13B	PRKAB2
Description		protein phosphatase 1 regulatory subunit 13B	protein kinase AMP-activated non-catalytic subunit beta 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	P53 Binding Protein Binding	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Neuron Death	Protein Phosphorylation Fatty Acid Biosynthetic Process Signal Transduction Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 26426971) General risk tolerance (MTAG) ( 30643258) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglycerides ( 30275531)
Interacting Genes		72 interacting genes: ACSF3 APC ARHGAP45 BFSP2 BRCA1 C2orf42 CAPN7 CBY2 CCDC102B CCDC184 CCHCR1 CDC5L CEP57 CEP63 CGN CKS1B DEUP1 DGCR6L DIRAS1 DTNB FAM184A FAM90A1 GAS2L2 GINS4 GOLGA1 HMG20B HNRNPUL1 KHDRBS1 KHDRBS3 KIF9 KIFC3 KRT20 KRT4 LMNB1 LMNB2 LMO1 LMO3 LNX1 MATN4 MCRS1 MIPOL1 MIS18A MLH1 NAP1L2 NDC80 NEK7 NHSL2 PLEKHA5 PPFIA3 PPP1CA PPP1R18 PRKAB2 PRPH PRR35 RALBP1 RASAL3 RASSF8 SALL1 SOGA1 TCL1A TEKT4 TEX12 TEX9 TNIK TP63 TP73 TRAF1 TSG101 TSGA10 TXLNA ZGPAT ZZZ3	170 interacting genes: ABHD11 ADAMTSL4 ANAPC11 ARID5A AUNIP AVP BANP BEND5 BHLHB9 BLZF1 C11orf1 C19orf54 C2orf42 C3orf36 CALCOCO2 CASP2 CASP6 CCDC28B CCDC33 CDC14B CDSN CDX4 CFP CREB3L1 CRX CSNK2B CYSRT1 DAO DDAH2 DDIT4L DICER1 DOK3 DST ELL2 EPM2A ESM1 FDX1 FLNC GATA1 GATAD2B GCSAML GET4 GOLGA2 GOLGA6L9 GORASP2 GRAPL GRN GSC2 IHO1 IKZF1 IKZF3 IL37 IRAK1BP1 KATNBL1 KCTD5 KHDC4 KLF15 KRBOX4 KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP4-5 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LHX3 LRIF1 LZTS1 LZTS2 MAGED1 MAJIN MDFI MEOX2 METTL27 MORN3 NAB2 NEBL NHLRC4 NUTM1 OXER1 PDE6G PDE6H PFDN5 PIAS2 PNMA1 PPP1R13B PPP1R16A PRDM14 PRKAA1 PRKAG1 PRKAG2 PSMD11 PSME3 PYGM QKI RAB3IP RACK1 RBM48 RBPMS REL RHEBL1 RIMBP3 RNF144B ROR2 RPH3AL SAMD4A SERTAD2 SMARCB1 SMUG1 SPRY1 SPRY2 SSC4D SSX2IP STX11 STX19 TADA2A TASOR2 TCF12 TCF19 TCF4 TCF7L2 TGM7 TLE5 TNNI1 TP53 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM14 TRIM35 TRIM42 TRIM54 TRIM55 TRIM63 TSR2 TTC23 UBXN11 USP54 VBP1 VPS28 WDR83 YPEL3 YY1AP1 ZBTB32 ZC2HC1C ZFP90 ZMYND19 ZNF177 ZNF236 ZNF474 ZNF526 ZNF559-ZNF177 ZNF581
Entrez ID		23368	5565
HPRD ID		07345	04117
Ensembl ID		ENSG00000088808	ENSG00000131791
Uniprot IDs		Q96KQ4	O43741
PDB IDs		6HL5	2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E
Enriched GO Terms of Interacting Partners?
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