IL24 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		IL24	PALB2
Description		interleukin 24	partner and localizer of BRCA2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Protein-containing Complex
	Molecular Function	Cytokine Activity Protein Binding	DNA Binding Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Migration Wound Healing Serine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways		Interleukin-20 family signaling	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Bipolar disorder ( 17554300)
Interacting Genes		26 interacting genes: AKT1 APC ATM BAG4 CASP8 CCR5 CLU DCD ESR2 FBXW7 HMMR HRAS IL20RA KRAS LSP1 NOTCH2 PALB2 PARP1 PIK3CA PTEN RAD51 RARG RB1CC1 RIPK3 SMAD4 UBE3A	32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		11009	79728
HPRD ID		04995	07966
Ensembl ID		ENSG00000162892	ENSG00000083093
Uniprot IDs		Q13007	H3BN63 Q86YC2
PDB IDs		6DF3 6GG1	2W18 3EU7
Enriched GO Terms of Interacting Partners?
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