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H2BC21 and CREBBP
Data Source:
BioGRID
(enzymatic study)
H2BC21
CREBBP
Description
H2B clustered histone 21
CREB binding protein
Image
GO Annotations
Cellular Component
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Extracellular Exosome
Histone Acetyltransferase Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Nuclear Body
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Activating Transcription Factor Binding
P53 Binding
Chromatin Binding
Damaged DNA Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Histone Acetyltransferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Acetyltransferase Activity
Chromatin DNA Binding
MRF Binding
Peptide-lysine-N-acetyltransferase Activity
Biological Process
Innate Immune Response In Mucosa
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Protein Acetylation
Signal Transduction
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Regulation Of Smoothened Signaling Pathway
Viral Process
Histone Acetylation
N-terminal Peptidyl-lysine Acetylation
Protein Phosphopantetheinylation
Regulation Of Lipid Metabolic Process
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Destabilization
Positive Regulation Of Type I Interferon Production
Cellular Response To UV
Homeostatic Process
Embryonic Digit Morphogenesis
Regulation Of Apoptotic Process
Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Protein-containing Complex Assembly
Regulation Of Cellular Response To Heat
Beta-catenin-TCF Complex Assembly
Histone Glutamine Methylation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Regulation of gene expression by Hypoxia-inducible Factor
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
PPARA activates gene expression
PPARA activates gene expression
Formation of the beta-catenin:TCF transactivating complex
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
HATs acetylate histones
Attenuation phase
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
CD209 (DC-SIGN) signaling
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
FOXO-mediated transcription of cell death genes
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Drugs
9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
Diseases
Rubinstein-Taybi syndrome
GWAS
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Heel bone mineral density (
30598549
)
Metabolite levels (HVA/5-HIAA ratio) (
23319000
)
Neutrophil count (
32888494
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Nonsyndromic cleft lip with or without cleft palate (
25775280
)
Obesity-related traits (
23251661
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
QT interval (
24952745
)
QT interval (drug interaction) (
23459443
)
White blood cell count (
32888494
)
Interacting Genes
77 interacting genes:
AIRE
AKT1
ANP32A
AP2M1
ARID1B
ATF2
ATXN7L3
BARD1
BRD2
BRD7
CDK9
CREBBP
DNMT3L
DYRK2
EP300
GADD45A
GATAD2A
GATAD2B
GZMA
H2AC20
HDAC2
HIPK2
HIRA
HIRIP3
HSPD1
IL33
IL7R
KAT2A
KAT2B
KPNA1
LALBA
LOX
MAP4K4
MDM2
MSL1
MSL2
NAP1L4
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT6
PTMA
RAG1
RCC1
RNF168
RNF20
RNF8
RPS6KA5
SAP30
SART3
SIRT7
SMARCA4
SMU1
SPANXN2
SSRP1
STK38
STK4
TAF1A
TAF1B
TBL1X
TBL1XR1
TCF20
TGM2
TNPO1
TRAF6
TSPY1
UBC
UBE2A
USP12
USP15
USP22
USP46
USP49
USP8
VRK1
295 interacting genes:
ACTA2
ACVR1
AFP
AIRE
AKT1
ALX1
ANAPC5
ANAPC7
AP1B1
APC
AR
ATF1
ATF3
ATF4
ATF7IP
ATRX
BCL3
BCL6
BRCA1
BRIP1
CALCOCO1
CAMK4
CARM1
CASP8AP2
CBX4
CDC25B
CDH2
CDK5RAP3
CDX2
CEBPA
CEBPB
CEBPD
CENPJ
CHAF1A
CHD3
CHUK
CITED1
CITED2
CNOT3
CPSF4
CREB1
CREM
CRX
CSK
CSNK2A1
CSNK2A2
CTBP1
CTNNB1
CUX1
DACH1
DAXX
DDX17
DDX5
DEK
DYRK1A
E2F1
E2F3
E2F5
EBF1
EGR1
EID1
EID3
EIF2B1
EIF3D
ELF3
ELK1
EP300
ESR1
ETS1
ETS2
EWSR1
FAF1
FBXL19
FBXO38
FGFR1
FHL2
FOS
FOXM1
FOXO1
FOXO4
GABPA
GAK
GATA1
GATAD2A
GCM1
GLI3
GMEB1
GMEB2
GTF2B
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H4-16
H4C1
HBP1
HCK
HDAC1
HDAC3
HIF1A
HIPK1
HIPK2
HIPK3
HLF
HMGA1
HMGB1
HMGB2
HMGXB4
HNF1A
HNF1B
HNF4A
HOXA10
HOXA11
HOXA9
HOXB1
HOXB2
HOXB3
HOXB4
HOXB6
HOXB7
HOXB9
HOXD10
HOXD12
HOXD13
HOXD4
HSF1
HTT
IKBKG
IRF1
IRF3
IRF5
IRF7
JDP2
JUN
KAT2A
KAT2B
KAT5
KAT6A
KDM3B
KHDRBS1
KISS1
KLF1
KLF13
KLF4
KLF5
KMT2A
KPNA2
KPNA6
LDLR
LIG4
LYN
MAF
MAFG
MAML1
MAML2
MAP3K5
MAPK1
MAPK10
MAPK3
MAPT
MBD2
MDC1
MDM2
MECOM
MED25
MGMT
MIER1
MKNK1
MSH2
MSH6
MSX1
MYB
MYBL1
MYBL2
MYC
MYOD1
N4BP2
NAP1L1
NCOA1
NCOA2
NCOA3
NCOA6
NEUROG1
NFATC2
NFATC4
NFE2
NFE2L2
NFIA
NFIC
NKX2-1
NLK
NPAS2
NPAT
NR3C1
NR5A1
NUP98
ONECUT1
PARP1
PAX5
PBX1
PCMT1
PCNA
PELP1
PHOX2A
PIAS1
PIAS2
PIAS3
PLAGL1
PML
POLR2A
POU1F1
POU2F3
PPARG
PPARGC1A
PPP1R8
PPP2R2A
PRKCD
PRLR
PROX1
PSME3
PTMA
PTPRF
RAD23A
RBBP4
RBBP7
RBCK1
RELA
RNF111
RPL3
RPL35
RPS6KA1
RPS6KA3
RPS6KA5
RXRG
SERTAD1
SERTAD2
SERTAD3
SETDB1
SH3GL1
SMAD2
SMAD3
SMAD4
SND1
SNIP1
SOX9
SP100
SPI1
SPIB
SRCAP
SREBF1
SREBF2
SRF
SS18L1
STAT1
STAT2
STAT3
STAT4
STAT6
SUMO1
SUV39H1
TACC2
TAF6L
TCF12
TCF3
TDG
TFDP1
TGS1
THRA
TOPORS
TP53
TP73
TRERF1
TRIP10
TRIP4
TSPYL2
UBE2D1
UBE2I
UBTF
UIMC1
VDR
WDR77
WT1
XAF1
XRCC6
YWHAH
ZBTB17
ZBTB2
ZCCHC7
ZHX1
ZMYM2
ZMYM5
ZNF451
ZNF639
ZNFX1
Entrez ID
8349
1387
HPRD ID
03494
02534
Ensembl ID
ENSG00000184678
ENSG00000005339
Uniprot IDs
Q16778
Q92793
PDB IDs
4NFT
6A7U
6KBB
6M4D
6M4G
6M4H
1JSP
1LIQ
1RDT
1WO3
1WO4
1WO5
1WO6
1WO7
1ZOQ
2D82
2KJE
2KWF
2L84
2L85
2LXS
2LXT
2N1A
2RNY
3DWY
3P1C
3P1D
3P1E
3P1F
3SVH
4A9K
4N3W
4N4F
4NR4
4NR5
4NR6
4NR7
4NYV
4NYW
4NYX
4OUF
4TQN
4TS8
4WHU
4YK0
5CGP
5DBM
5EIC
5ENG
5EP7
5GH9
5H85
5I83
5I86
5I89
5I8B
5I8G
5J0D
5JEM
5KTU
5KTW
5KTX
5LPJ
5LPL
5MME
5MMG
5MPK
5MPN
5MPZ
5MQE
5MQG
5MQK
5NLK
5NRW
5NU3
5OWK
5SVH
5TB6
5W0E
5W0F
5W0L
5W0Q
5XXH
6ALB
6ALC
6AXQ
6AY3
6AY5
6DMK
6ES5
6ES6
6ES7
6FQO
6FQT
6FQU
6FR0
6FRF
6QST
6SQE
6SQF
6SQM
6SXX
6YIJ
6YIK
6YIL
6YIM
7JFL
7JFM
Enriched GO Terms of Interacting Partners
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