H2BC21 and RAG1

Data Source:
BioGRID (far western blotting)

		H2BC21	RAG1
Description		H2B clustered histone 21	recombination activating 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Visual Learning Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Behavioral Fear Response
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation	Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS			Rheumatoid arthritis ( 24390342)
Interacting Genes		77 interacting genes: AIRE AKT1 ANP32A AP2M1 ARID1B ATF2 ATXN7L3 BARD1 BRD2 BRD7 CDK9 CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA H2AC20 HDAC2 HIPK2 HIRA HIRIP3 HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF168 RNF20 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SMU1 SPANXN2 SSRP1 STK38 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TRAF6 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 USP8 VRK1	17 interacting genes: APP DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4-16 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 UBC UBE2C UBE2D1 UBE2D2 UBE2H
Entrez ID		8349	5896
HPRD ID		03494	01556
Ensembl ID		ENSG00000184678	ENSG00000166349
Uniprot IDs		Q16778	P15918
PDB IDs		4NFT 6A7U 6KBB 6M4D 6M4G 6M4H
Enriched GO Terms of Interacting Partners?
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