H2BC21 and IL33

Data Source:
BioGRID (pull down)

		H2BC21	IL33
Description		H2B clustered histone 21	interleukin 33
Image
GO Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Transport Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Interleukin-33 Receptor Binding Cytokine Activity Protein Binding
	Biological Process	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Microglial Cell Activation Involved In Immune Response Negative Regulation Of Immunoglobulin Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Leukocyte Migration Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Cellular Defense Response Positive Regulation Of Gene Expression Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interferon-gamma Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Microglial Cell Proliferation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Proliferation Positive Regulation Of Neuroinflammatory Response Positive Regulation Of CD86 Production Positive Regulation Of CD80 Production
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation	PIP3 activates AKT signaling Ub-specific processing proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 21804549 31361310 31959851 30929738 20860503 27182965 32296059 31619474 29785011 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738 24241537 29273806) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Chronic rhinosinusitis ( 30643255) Eczema ( 31361310) Endometriosis ( 23472165) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Periodontal microbiota ( 22699663) Self-reported allergy ( 23817569) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Small cell lung carcinoma ( 28604730)
Interacting Genes		77 interacting genes: AIRE AKT1 ANP32A AP2M1 ARID1B ATF2 ATXN7L3 BARD1 BRD2 BRD7 CDK9 CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA H2AC20 HDAC2 HIPK2 HIRA HIRIP3 HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF168 RNF20 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SMU1 SPANXN2 SSRP1 STK38 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TRAF6 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 USP8 VRK1	5 interacting genes: CASP1 CRMP1 H2AC18 H2BC21 IL1RL1
Entrez ID		8349	90865
HPRD ID		03494	12275
Ensembl ID		ENSG00000184678	ENSG00000137033
Uniprot IDs		Q16778	O95760
PDB IDs		4NFT 6A7U 6KBB 6M4D 6M4G 6M4H	2KLL 4KC3
Enriched GO Terms of Interacting Partners?
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