H2BC21 and AP2M1

Data Source:
BioGRID (two hybrid)

		H2BC21	AP2M1
Description		H2B clustered histone 21	adaptor related protein complex 2 subunit mu 1
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GO Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Cytosol Extracellular Exosome	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Endocytic Vesicle Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Ion Channel Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Cellular Protein-containing Complex Assembly Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis Regulation Of Vesicle Size Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Interacting Genes		77 interacting genes: AIRE AKT1 ANP32A AP2M1 ARID1B ATF2 ATXN7L3 BARD1 BRD2 BRD7 CDK9 CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA H2AC20 HDAC2 HIPK2 HIRA HIRIP3 HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF168 RNF20 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SMU1 SPANXN2 SSRP1 STK38 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TRAF6 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 USP8 VRK1	76 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD3D CDK11B CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HTR6 IKZF1 KCNJ11 KNOP1 LAMP1 LTB4R2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TMA16 UBC UTP25 ZBTB8A ZNF581
Entrez ID		8349	1173
HPRD ID		03494	03014
Ensembl ID		ENSG00000184678	ENSG00000161203
Uniprot IDs		Q16778	B4DNB9 E9PFW3 Q96CW1
PDB IDs		4NFT 6A7U 6KBB 6M4D 6M4G 6M4H	1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?
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