CREBBP and PSME3

Data Source:
BioGRID (enzymatic study)

		CREBBP	PSME3
Description		CREB binding protein	proteasome activator subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Membrane
	Molecular Function	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding P53 Binding Chromatin Binding Damaged DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Chromatin DNA Binding MRF Binding Peptide-lysine-N-acetyltransferase Activity	P53 Binding Protein Binding Identical Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Acetylation Signal Transduction Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Smoothened Signaling Pathway Viral Process Histone Acetylation N-terminal Peptidyl-lysine Acetylation Protein Phosphopantetheinylation Regulation Of Lipid Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To UV Homeostatic Process Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein-containing Complex Assembly Regulation Of Cellular Response To Heat Beta-catenin-TCF Complex Assembly Histone Glutamine Methylation	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process Cell Cycle Positive Regulation Of Endopeptidase Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
Diseases		Rubinstein-Taybi syndrome
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Neutrophil count ( 32888494) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Obesity-related traits ( 23251661) Pre-treatment viral load in HIV-1 infection ( 31219150) QT interval ( 24952745) QT interval (drug interaction) ( 23459443) White blood cell count ( 32888494)
Interacting Genes		295 interacting genes: ACTA2 ACVR1 AFP AIRE AKT1 ALX1 ANAPC5 ANAPC7 AP1B1 APC AR ATF1 ATF3 ATF4 ATF7IP ATRX BCL3 BCL6 BRCA1 BRIP1 CALCOCO1 CAMK4 CARM1 CASP8AP2 CBX4 CDC25B CDH2 CDK5RAP3 CDX2 CEBPA CEBPB CEBPD CENPJ CHAF1A CHD3 CHUK CITED1 CITED2 CNOT3 CPSF4 CREB1 CREM CRX CSK CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CUX1 DACH1 DAXX DDX17 DDX5 DEK DYRK1A E2F1 E2F3 E2F5 EBF1 EGR1 EID1 EID3 EIF2B1 EIF3D ELF3 ELK1 EP300 ESR1 ETS1 ETS2 EWSR1 FAF1 FBXL19 FBXO38 FGFR1 FHL2 FOS FOXM1 FOXO1 FOXO4 GABPA GAK GATA1 GATAD2A GCM1 GLI3 GMEB1 GMEB2 GTF2B H2BC21 H2BC3 H3-3A H3-4 H3C1 H4-16 H4C1 HBP1 HCK HDAC1 HDAC3 HIF1A HIPK1 HIPK2 HIPK3 HLF HMGA1 HMGB1 HMGB2 HMGXB4 HNF1A HNF1B HNF4A HOXA10 HOXA11 HOXA9 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD12 HOXD13 HOXD4 HSF1 HTT IKBKG IRF1 IRF3 IRF5 IRF7 JDP2 JUN KAT2A KAT2B KAT5 KAT6A KDM3B KHDRBS1 KISS1 KLF1 KLF13 KLF4 KLF5 KMT2A KPNA2 KPNA6 LDLR LIG4 LYN MAF MAFG MAML1 MAML2 MAP3K5 MAPK1 MAPK10 MAPK3 MAPT MBD2 MDC1 MDM2 MECOM MED25 MGMT MIER1 MKNK1 MSH2 MSH6 MSX1 MYB MYBL1 MYBL2 MYC MYOD1 N4BP2 NAP1L1 NCOA1 NCOA2 NCOA3 NCOA6 NEUROG1 NFATC2 NFATC4 NFE2 NFE2L2 NFIA NFIC NKX2-1 NLK NPAS2 NPAT NR3C1 NR5A1 NUP98 ONECUT1 PARP1 PAX5 PBX1 PCMT1 PCNA PELP1 PHOX2A PIAS1 PIAS2 PIAS3 PLAGL1 PML POLR2A POU1F1 POU2F3 PPARG PPARGC1A PPP1R8 PPP2R2A PRKCD PRLR PROX1 PSME3 PTMA PTPRF RAD23A RBBP4 RBBP7 RBCK1 RELA RNF111 RPL3 RPL35 RPS6KA1 RPS6KA3 RPS6KA5 RXRG SERTAD1 SERTAD2 SERTAD3 SETDB1 SH3GL1 SMAD2 SMAD3 SMAD4 SND1 SNIP1 SOX9 SP100 SPI1 SPIB SRCAP SREBF1 SREBF2 SRF SS18L1 STAT1 STAT2 STAT3 STAT4 STAT6 SUMO1 SUV39H1 TACC2 TAF6L TCF12 TCF3 TDG TFDP1 TGS1 THRA TOPORS TP53 TP73 TRERF1 TRIP10 TRIP4 TSPYL2 UBE2D1 UBE2I UBTF UIMC1 VDR WDR77 WT1 XAF1 XRCC6 YWHAH ZBTB17 ZBTB2 ZCCHC7 ZHX1 ZMYM2 ZMYM5 ZNF451 ZNF639 ZNFX1	64 interacting genes: ABCF3 ADAP1 AICDA ATN1 ATP5F1B BBS2 CASP3 CASP6 CASP7 CDC25B CDC42 CDR2L CHEK2 COIL CREBBP DEPTOR DIP2A DMRT3 DTNBP1 DVL3 EAF1 EAF2 FAM90A1 FBXL12 FBXL19 FOXD4L1 FXR2 GPATCH2L HSPA5 INPP5J ITPKB KANSL1 KBTBD7 KLF2 LNX1 MDM2 MEOX2 NCOA3 NTAQ1 NUDT18 PFDN5 PIAS1 PICK1 PRKAB2 PRR13 RDX RNF111 RPH3AL RPS27 SERF2 SIRT1 SMURF1 SPG7 TBP TBXA2R THAP10 TNFAIP8L1 TP53 TXN2 UBE2H UBE2I WDR25 YWHAQ ZCCHC10
Entrez ID		1387	10197
HPRD ID		02534	05500
Ensembl ID		ENSG00000005339	ENSG00000131467
Uniprot IDs		Q92793	A0A024R203 B3KQ25 P61289 Q6MZZ1 V9HWJ8
PDB IDs		1JSP 1LIQ 1RDT 1WO3 1WO4 1WO5 1WO6 1WO7 1ZOQ 2D82 2KJE 2KWF 2L84 2L85 2LXS 2LXT 2N1A 2RNY 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K 4N3W 4N4F 4NR4 4NR5 4NR6 4NR7 4NYV 4NYW 4NYX 4OUF 4TQN 4TS8 4WHU 4YK0 5CGP 5DBM 5EIC 5ENG 5EP7 5GH9 5H85 5I83 5I86 5I89 5I8B 5I8G 5J0D 5JEM 5KTU 5KTW 5KTX 5LPJ 5LPL 5MME 5MMG 5MPK 5MPN 5MPZ 5MQE 5MQG 5MQK 5NLK 5NRW 5NU3 5OWK 5SVH 5TB6 5W0E 5W0F 5W0L 5W0Q 5XXH 6ALB 6ALC 6AXQ 6AY3 6AY5 6DMK 6ES5 6ES6 6ES7 6FQO 6FQT 6FQU 6FR0 6FRF 6QST 6SQE 6SQF 6SQM 6SXX 6YIJ 6YIK 6YIL 6YIM 7JFL 7JFM
Enriched GO Terms of Interacting Partners?
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