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CREBBP and CHUK
Data Source:
HPRD
(two hybrid, in vivo)
CREBBP
CHUK
Description
CREB binding protein
component of inhibitor of nuclear factor kappa B kinase complex
Image
GO Annotations
Cellular Component
Histone Acetyltransferase Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Nuclear Body
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Molecular Function
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Activating Transcription Factor Binding
P53 Binding
Chromatin Binding
Damaged DNA Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Histone Acetyltransferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Acetyltransferase Activity
Chromatin DNA Binding
MRF Binding
Peptide-lysine-N-acetyltransferase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Transferrin Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Protein Acetylation
Signal Transduction
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Regulation Of Smoothened Signaling Pathway
Viral Process
Histone Acetylation
N-terminal Peptidyl-lysine Acetylation
Protein Phosphopantetheinylation
Regulation Of Lipid Metabolic Process
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Destabilization
Positive Regulation Of Type I Interferon Production
Cellular Response To UV
Homeostatic Process
Embryonic Digit Morphogenesis
Regulation Of Apoptotic Process
Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Protein-containing Complex Assembly
Regulation Of Cellular Response To Heat
Beta-catenin-TCF Complex Assembly
Histone Glutamine Methylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-independent Toll-like Receptor Signaling Pathway
Skeletal Muscle Contraction
Protein Phosphorylation
Inflammatory Response
Immune Response
I-kappaB Kinase/NF-kappaB Signaling
I-kappaB Phosphorylation
Rho Protein Signal Transduction
Response To Virus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Response To Acetate
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Lipopolysaccharide
Positive Regulation Of Interferon-alpha Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Reactive Oxygen Species
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Response To Drug
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Amino Acid
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Stress-activated MAPK Cascade
Response To Cholecystokinin
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Virus
Pathways
Regulation of gene expression by Hypoxia-inducible Factor
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
PPARA activates gene expression
PPARA activates gene expression
Formation of the beta-catenin:TCF transactivating complex
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
HATs acetylate histones
Attenuation phase
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
CD209 (DC-SIGN) signaling
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
FOXO-mediated transcription of cell death genes
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
Aminosalicylic acid
Mesalazine
Sulfasalazine
Acetylcysteine
Diseases
Rubinstein-Taybi syndrome
Cocoon syndrome
GWAS
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Heel bone mineral density (
30598549
)
Metabolite levels (HVA/5-HIAA ratio) (
23319000
)
Neutrophil count (
32888494
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Nonsyndromic cleft lip with or without cleft palate (
25775280
)
Obesity-related traits (
23251661
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
QT interval (
24952745
)
QT interval (drug interaction) (
23459443
)
White blood cell count (
32888494
)
Liver enzyme levels (
18940312
)
Psoriasis (
28537254
)
Type 2 diabetes (
30054458
)
Interacting Genes
295 interacting genes:
ACTA2
ACVR1
AFP
AIRE
AKT1
ALX1
ANAPC5
ANAPC7
AP1B1
APC
AR
ATF1
ATF3
ATF4
ATF7IP
ATRX
BCL3
BCL6
BRCA1
BRIP1
CALCOCO1
CAMK4
CARM1
CASP8AP2
CBX4
CDC25B
CDH2
CDK5RAP3
CDX2
CEBPA
CEBPB
CEBPD
CENPJ
CHAF1A
CHD3
CHUK
CITED1
CITED2
CNOT3
CPSF4
CREB1
CREM
CRX
CSK
CSNK2A1
CSNK2A2
CTBP1
CTNNB1
CUX1
DACH1
DAXX
DDX17
DDX5
DEK
DYRK1A
E2F1
E2F3
E2F5
EBF1
EGR1
EID1
EID3
EIF2B1
EIF3D
ELF3
ELK1
EP300
ESR1
ETS1
ETS2
EWSR1
FAF1
FBXL19
FBXO38
FGFR1
FHL2
FOS
FOXM1
FOXO1
FOXO4
GABPA
GAK
GATA1
GATAD2A
GCM1
GLI3
GMEB1
GMEB2
GTF2B
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H4-16
H4C1
HBP1
HCK
HDAC1
HDAC3
HIF1A
HIPK1
HIPK2
HIPK3
HLF
HMGA1
HMGB1
HMGB2
HMGXB4
HNF1A
HNF1B
HNF4A
HOXA10
HOXA11
HOXA9
HOXB1
HOXB2
HOXB3
HOXB4
HOXB6
HOXB7
HOXB9
HOXD10
HOXD12
HOXD13
HOXD4
HSF1
HTT
IKBKG
IRF1
IRF3
IRF5
IRF7
JDP2
JUN
KAT2A
KAT2B
KAT5
KAT6A
KDM3B
KHDRBS1
KISS1
KLF1
KLF13
KLF4
KLF5
KMT2A
KPNA2
KPNA6
LDLR
LIG4
LYN
MAF
MAFG
MAML1
MAML2
MAP3K5
MAPK1
MAPK10
MAPK3
MAPT
MBD2
MDC1
MDM2
MECOM
MED25
MGMT
MIER1
MKNK1
MSH2
MSH6
MSX1
MYB
MYBL1
MYBL2
MYC
MYOD1
N4BP2
NAP1L1
NCOA1
NCOA2
NCOA3
NCOA6
NEUROG1
NFATC2
NFATC4
NFE2
NFE2L2
NFIA
NFIC
NKX2-1
NLK
NPAS2
NPAT
NR3C1
NR5A1
NUP98
ONECUT1
PARP1
PAX5
PBX1
PCMT1
PCNA
PELP1
PHOX2A
PIAS1
PIAS2
PIAS3
PLAGL1
PML
POLR2A
POU1F1
POU2F3
PPARG
PPARGC1A
PPP1R8
PPP2R2A
PRKCD
PRLR
PROX1
PSME3
PTMA
PTPRF
RAD23A
RBBP4
RBBP7
RBCK1
RELA
RNF111
RPL3
RPL35
RPS6KA1
RPS6KA3
RPS6KA5
RXRG
SERTAD1
SERTAD2
SERTAD3
SETDB1
SH3GL1
SMAD2
SMAD3
SMAD4
SND1
SNIP1
SOX9
SP100
SPI1
SPIB
SRCAP
SREBF1
SREBF2
SRF
SS18L1
STAT1
STAT2
STAT3
STAT4
STAT6
SUMO1
SUV39H1
TACC2
TAF6L
TCF12
TCF3
TDG
TFDP1
TGS1
THRA
TOPORS
TP53
TP73
TRERF1
TRIP10
TRIP4
TSPYL2
UBE2D1
UBE2I
UBTF
UIMC1
VDR
WDR77
WT1
XAF1
XRCC6
YWHAH
ZBTB17
ZBTB2
ZCCHC7
ZHX1
ZMYM2
ZMYM5
ZNF451
ZNF639
ZNFX1
81 interacting genes:
AKT1
AKT2
AMBRA1
ATR
BCL10
BCL3
BTRC
CASP8
CDC37
CHEK1
COPS5
CREBBP
CSF2RA
CSNK2A1
CTNNB1
CUEDC2
CUL1
DCUN1D5
E2F4
EIF2AK2
ELP1
ERBIN
ESR1
FKBP5
FOXO3
H3-4
H3C14
HSP90AA1
HSP90AB1
HTT
IFIT5
IKBKB
IKBKE
IKBKG
IRS1
MAP3K1
MAP3K11
MAP3K14
MAP3K4
MAP3K7
MAP3K8
NCOA3
NCOR1
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NLRP4
NOTCH3
NR2C2
PAX8
PEBP1
PIAS1
PRKCB
PRKCI
PRKCQ
PRKDC
PTPN11
RELA
RICTOR
RIPK2
RPL27
SRC
SRPK1
SRPK2
STAP2
TANK
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TRAF2
TRAF3IP2
TRAF4
TRIM27
TRPC4AP
UBC
UBE2E3
UBE2I
UBE2N
Entrez ID
1387
1147
HPRD ID
02534
02811
Ensembl ID
ENSG00000005339
ENSG00000213341
Uniprot IDs
Q92793
O15111
PDB IDs
1JSP
1LIQ
1RDT
1WO3
1WO4
1WO5
1WO6
1WO7
1ZOQ
2D82
2KJE
2KWF
2L84
2L85
2LXS
2LXT
2N1A
2RNY
3DWY
3P1C
3P1D
3P1E
3P1F
3SVH
4A9K
4N3W
4N4F
4NR4
4NR5
4NR6
4NR7
4NYV
4NYW
4NYX
4OUF
4TQN
4TS8
4WHU
4YK0
5CGP
5DBM
5EIC
5ENG
5EP7
5GH9
5H85
5I83
5I86
5I89
5I8B
5I8G
5J0D
5JEM
5KTU
5KTW
5KTX
5LPJ
5LPL
5MME
5MMG
5MPK
5MPN
5MPZ
5MQE
5MQG
5MQK
5NLK
5NRW
5NU3
5OWK
5SVH
5TB6
5W0E
5W0F
5W0L
5W0Q
5XXH
6ALB
6ALC
6AXQ
6AY3
6AY5
6DMK
6ES5
6ES6
6ES7
6FQO
6FQT
6FQU
6FR0
6FRF
6QST
6SQE
6SQF
6SQM
6SXX
6YIJ
6YIK
6YIL
6YIM
7JFL
7JFM
3BRT
5EBZ
5TQW
5TQX
5TQY
Enriched GO Terms of Interacting Partners
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