UGT1A4 and CYB5A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		UGT1A4	CYB5A
Description		UDP glucuronosyltransferase family 1 member A4	cytochrome b5 type A
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Retinoic Acid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity	Cytochrome-c Oxidase Activity Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Bilirubin Conjugation Heme Catabolic Process Cellular Glucuronidation	L-ascorbic Acid Metabolic Process Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport
Pathways		Glucuronidation Heme degradation Defective UGT1A4 causes hyperbilirubinemia	Vitamin C (ascorbate) metabolism
Drugs			Dimethyl Propionate Ester Heme
Diseases			Methemoglobinemia
GWAS		Hair greying ( 26926045) Liver disease biomarker ( 30576415) Plasma norclozapine levels in treatment-resistant schizophrenia ( 30922102) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)	Blood protein levels ( 30072576)
Interacting Genes		1 interacting genes: CYB5A	14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4
Entrez ID		54657	1528
HPRD ID		08402	08941
Ensembl ID		ENSG00000244474	ENSG00000166347
Uniprot IDs		P22310	A0A384ME44 P00167
PDB IDs			2I96
Enriched GO Terms of Interacting Partners?
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