CYB5A and UGT1A4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CYB5A	UGT1A4
Description		cytochrome b5 type A	UDP glucuronosyltransferase family 1 member A4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Cytochrome-c Oxidase Activity Enzyme Binding Heme Binding Metal Ion Binding	Retinoic Acid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity
	Biological Process	L-ascorbic Acid Metabolic Process Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport	Bilirubin Conjugation Heme Catabolic Process Cellular Glucuronidation
Pathways		Vitamin C (ascorbate) metabolism	Glucuronidation Heme degradation Defective UGT1A4 causes hyperbilirubinemia
Drugs		Dimethyl Propionate Ester Heme
Diseases		Methemoglobinemia
GWAS		Blood protein levels ( 30072576)	Hair greying ( 26926045) Liver disease biomarker ( 30576415) Plasma norclozapine levels in treatment-resistant schizophrenia ( 30922102) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	1 interacting genes: CYB5A
Entrez ID		1528	54657
HPRD ID		08941	08402
Ensembl ID		ENSG00000166347	ENSG00000244474
Uniprot IDs		A0A384ME44 P00167	P22310
PDB IDs		2I96
Enriched GO Terms of Interacting Partners?
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