CYB5A and CYP17A1

Number of citations of the paper that reports this interaction (PubMedID 9601054)
8

Data Source:
HPRD (in vitro)

		CYB5A	CYP17A1
Description		cytochrome b5 type A	cytochrome P450 family 17 subfamily A member 1
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Axon Neuronal Cell Body
	Molecular Function	Cytochrome-c Oxidase Activity Enzyme Binding Heme Binding Metal Ion Binding	Steroid 17-alpha-monooxygenase Activity Iron Ion Binding Oxygen Binding Heme Binding 17-alpha-hydroxyprogesterone Aldolase Activity
	Biological Process	L-ascorbic Acid Metabolic Process Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport	Steroid Biosynthetic Process Androgen Biosynthetic Process Glucocorticoid Biosynthetic Process Sex Differentiation Steroid Metabolic Process Hormone Biosynthetic Process Progesterone Metabolic Process Oxidation-reduction Process
Pathways		Vitamin C (ascorbate) metabolism	Androgen biosynthesis Glucocorticoid biosynthesis Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Drugs		Dimethyl Propionate Ester Heme	NADH Progesterone Abiraterone
Diseases		Methemoglobinemia	46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
GWAS		Blood protein levels ( 30072576)	Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758) Blood pressure ( 21572416 24001895 21909110) Colorectal cancer ( 26965516) Coronary artery disease ( 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878 28739976 27618452 25249183) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hip circumference ( 25673412) Hypertension ( 31879980 25249183 30487518) Mean arterial pressure ( 26390057 27618448 30487518) Microalbuminuria ( 26631737) Myocardial infarction ( 26343387) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Pulse pressure ( 27841878 28739976 30487518) Schizophrenia ( 25056061 29483656 23974872) Sodium levels ( 29403010) Systolic blood pressure ( 26390057 27736895 28135244 19430479 19430483 27841878 21909115 28739976 27618447 27618452 25249183 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Waist circumference ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	15 interacting genes: APC ATP5F1E BARX1 CDO1 CHEK2 CYB5A ERBB2 FZR1 HSP90AB1 IGF1R POR PTPRJ RPAIN STK11 TIGD7
Entrez ID		1528	1586
HPRD ID		08941	01944
Ensembl ID		ENSG00000166347	ENSG00000148795
Uniprot IDs		A0A384ME44 P00167	P05093 Q1HB44
PDB IDs		2I96	2C17 3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY 4NKZ 5IRQ 5IRV 5UYS 6CHI 6CIR 6CIZ
Enriched GO Terms of Interacting Partners?
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