CYB5A and CYP3A4

Number of citations of the paper that reports this interaction (PubMedID 15680923)
23

Data Source:
BioGRID (pull down)

		CYB5A	CYP3A4
Description		cytochrome b5 type A	cytochrome P450 family 3 subfamily A member 4
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Cytochrome-c Oxidase Activity Enzyme Binding Heme Binding Metal Ion Binding	Monooxygenase Activity Steroid Binding Iron Ion Binding Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxygen Binding Enzyme Binding Heme Binding Vitamin D3 25-hydroxylase Activity Caffeine Oxidase Activity Quinine 3-monooxygenase Activity Testosterone 6-beta-hydroxylase Activity Aromatase Activity Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity 1,8-cineole 2-exo-monooxygenase Activity
	Biological Process	L-ascorbic Acid Metabolic Process Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport	Lipid Hydroxylation Lipid Metabolic Process Steroid Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Heterocycle Metabolic Process Oxidation-reduction Process Oxidative Demethylation
Pathways		Vitamin C (ascorbate) metabolism	Xenobiotics Aflatoxin activation and detoxification Biosynthesis of maresin-like SPMs
Drugs		Dimethyl Propionate Ester Heme	Glutathione Isoniazid Paliperidone Pradefovir Mesylate Diacerein
Diseases		Methemoglobinemia
GWAS		Blood protein levels ( 30072576)	Metabolic traits ( 21886157) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Pre-treatment viral load in HIV-1 infection ( 31219150) Sex hormone levels ( 26014426) Tacrolimus trough concentration in kidney transplant patients ( 29160300) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875)
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	8 interacting genes: CYB5A CYP2C9 GK POR PRKACA PRKCA STUB1 UGT2B7
Entrez ID		1528	1576
HPRD ID		08941	00484
Ensembl ID		ENSG00000166347	ENSG00000160868
Uniprot IDs		A0A384ME44 P00167	P08684 Q6GRK0
PDB IDs		2I96	1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4D6Z 4D75 4D78 4D7D 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X 4NY4 5A1P 5A1R 5G5J 5TE8 5VC0 5VCC 5VCD 5VCE 5VCG 6BCZ 6BD5 6BD6 6BD7 6BD8 6BDH 6BDI 6BDK 6BDM 6OO9 6OOA 6OOB
Enriched GO Terms of Interacting Partners?
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