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POLA1 and POLA2
Number of citations of the paper that reports this interaction (PubMedID
8223465
)
47
Data Source:
HPRD
(in vivo, in vitro)
POLA1
POLA2
Description
DNA polymerase alpha 1, catalytic subunit
DNA polymerase alpha 2, accessory subunit
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytosol
Nuclear Matrix
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Cytosol
Molecular Function
Nucleotide Binding
Nucleoside Binding
DNA Binding
Chromatin Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Purine Nucleotide Binding
Pyrimidine Nucleotide Binding
Protein Kinase Binding
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Molecular_function
DNA Binding
DNA-directed DNA Polymerase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Viral Process
Telomere Maintenance Via Semi-conservative Replication
Mitotic DNA Replication Initiation
DNA Synthesis Involved In UV-damage Excision Repair
G1/S Transition Of Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
Telomere Maintenance Via Semi-conservative Replication
DNA Biosynthetic Process
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
Drugs
Cladribine
Clofarabine
Fludarabine
Nelarabine
Dacarbazine
Diseases
GWAS
Acne (severe) (
24927181
)
Interacting Genes
24 interacting genes:
CCNA2
CCNB1
CDC45
CDK1
CDK2
CDK2AP1
GINS4
GLRA2
HELB
IL1RAPL1
KLHL15
PARP1
POLA2
POLD1
POLE
PRIM2
RAD51
RB1
RBMS1
S100G
SERPINA3
SMC1A
TP53
XRCC5
41 interacting genes:
AGO2
AKTIP
APP
ARL2
ASCC2
ATL3
ATP5F1C
CATSPERZ
CPE
CRELD1
DCP2
DDX24
DHX34
EIF6
EZH2
FAM219A
FGFR3
FRZB
HDAC6
HELB
HGH1
IGFBP3
KCNE3
KDM2A
KLF6
LRPAP1
MFHAS1
NR4A1
PARP1
POLA1
PRIM2
PRPF38A
RBM23
SAC3D1
SETDB1
SNU13
STK40
TMEM216
ULK2
XPNPEP1
ZNRD2
Entrez ID
5422
23649
HPRD ID
02416
10160
Ensembl ID
ENSG00000101868
ENSG00000014138
Uniprot IDs
A6NMQ1
P09884
Q14181
PDB IDs
1K0P
1K18
1N5G
4Q5V
4QCL
4Y97
5EXR
5IUD
6AS7
2KEB
4E2I
4Y97
5EXR
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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