POLA1 and KLHL15

		POLA1	KLHL15
Description		DNA polymerase alpha 1, catalytic subunit	kelch like family member 15
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix	Nucleus Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Nucleoside Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Telomere Maintenance Via Semi-conservative Replication Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS			Prostate-specific antigen levels ( 28139693)
Interacting Genes		24 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 GLRA2 HELB IL1RAPL1 KLHL15 PARP1 POLA2 POLD1 POLE PRIM2 RAD51 RB1 RBMS1 S100G SERPINA3 SMC1A TP53 XRCC5	3 interacting genes: POLA1 PPP2R2B RBBP8
Entrez ID		5422	80311
HPRD ID		02416	09957
Ensembl ID		ENSG00000101868	ENSG00000174010
Uniprot IDs		A6NMQ1 P09884	Q96M94 V9HWF1
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7
Enriched GO Terms of Interacting Partners?
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