POLA1 and RBMS1

Number of citations of the paper that reports this interaction (PubMedID 10869558)
9

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		POLA1	RBMS1
Description		DNA polymerase alpha 1, catalytic subunit	RNA binding motif single stranded interacting protein 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix	Nucleus Cytosol Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Nucleoside Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Telomere Maintenance Via Semi-conservative Replication Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	DNA Replication RNA Processing
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS			Amyotrophic lateral sclerosis ( 19451621) Basal cell carcinoma ( 31174203) Chronotype ( 30696823) FEV1 ( 30804560) Idiopathic membranous nephropathy ( 21323541) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 30804560) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Peak expiratory flow ( 30804560) Systolic blood pressure ( 30224653) Tourette syndrome ( 30818990) Type 2 diabetes ( 22885922 30054458 29358691 30297969 20418489) Weight ( 28552196 31647587) White blood cell count ( 27863252)
Interacting Genes		24 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 GLRA2 HELB IL1RAPL1 KLHL15 PARP1 POLA2 POLD1 POLE PRIM2 RAD51 RB1 RBMS1 S100G SERPINA3 SMC1A TP53 XRCC5	2 interacting genes: POLA1 TFCP2
Entrez ID		5422	5937
HPRD ID		02416	03814
Ensembl ID		ENSG00000101868	ENSG00000153250
Uniprot IDs		A6NMQ1 P09884	A0A0S2Z499 A0A0S2Z4B3 B4DN88 P29558
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7	1X5O
Enriched GO Terms of Interacting Partners?
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