POLA2 and ATL3

		POLA2	ATL3
Description		DNA polymerase alpha 2, accessory subunit	atlastin GTPase 3
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GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane
	Molecular Function	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity	GTPase Activity Protein Binding GTP Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Protein Homooligomerization Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181)
Interacting Genes		41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2	2 interacting genes: APP POLA2
Entrez ID		23649	25923
HPRD ID		10160	13170
Ensembl ID		ENSG00000014138	ENSG00000184743
Uniprot IDs		Q14181	B4DXC4 F5H6I7 Q6DD88
PDB IDs		2KEB 4E2I 4Y97 5EXR	5VGR
Enriched GO Terms of Interacting Partners?
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