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POLA1 and POLD1
POLA1
POLD1
Description
DNA polymerase alpha 1, catalytic subunit
DNA polymerase delta 1, catalytic subunit
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytosol
Nuclear Matrix
Nucleotide-excision Repair Complex
Nuclear Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytosol
Membrane
Aggresome
Delta DNA Polymerase Complex
Molecular Function
Nucleotide Binding
Nucleoside Binding
DNA Binding
Chromatin Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Purine Nucleotide Binding
Pyrimidine Nucleotide Binding
Protein Kinase Binding
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Nucleotide Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
3'-5'-exodeoxyribonuclease Activity
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Viral Process
Telomere Maintenance Via Semi-conservative Replication
Mitotic DNA Replication Initiation
DNA Synthesis Involved In UV-damage Excision Repair
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA-dependent DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Response To UV
Translesion Synthesis
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Cellular Response To UV
DNA Damage Response, Detection Of DNA Damage
DNA Replication Proofreading
Fatty Acid Homeostasis
DNA Biosynthetic Process
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
Cytosolic iron-sulfur cluster assembly
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
Drugs
Cladribine
Clofarabine
Fludarabine
Nelarabine
Diseases
GWAS
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Obesity-related traits (
23251661
)
Interacting Genes
24 interacting genes:
CCNA2
CCNB1
CDC45
CDK1
CDK2
CDK2AP1
GINS4
GLRA2
HELB
IL1RAPL1
KLHL15
PARP1
POLA2
POLD1
POLE
PRIM2
RAD51
RB1
RBMS1
S100G
SERPINA3
SMC1A
TP53
XRCC5
18 interacting genes:
ATR
CCND3
CCNE1
CDK2
CDK4
CEP126
CHGB
GINS4
MCPH1
PCNA
POLA1
POLD2
POLD3
POLD4
TERF2IP
TREX2
WRNIP1
XRCC5
Entrez ID
5422
5424
HPRD ID
02416
08882
Ensembl ID
ENSG00000101868
ENSG00000062822
Uniprot IDs
A6NMQ1
P09884
A0A024R4F4
A0A087WYJ2
M0R2B7
P28340
Q308M6
Q59FA0
PDB IDs
1K0P
1K18
1N5G
4Q5V
4QCL
4Y97
5EXR
5IUD
6AS7
Enriched GO Terms of Interacting Partners
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