POLA2 and KLF6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	KLF6
Description		DNA polymerase alpha 2, accessory subunit	Kruppel like factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181)	Asthma (bronchodilator response) ( 23508266) Coronary artery calcification ( 23870195) Diastolic blood pressure ( 27841878) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549 28869591) Multiple sclerosis ( 31604244) Plasma anti-thyroglobulin levels ( 29678681)
Interacting Genes		41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2	16 interacting genes: APOM APP CELSR2 EHMT2 FBL GTF3C1 HDAC3 KLF4 LCOR NOP56 NUFIP1 PNO1 POLA2 SP1 TAF9 TP53
Entrez ID		23649	1316
HPRD ID		10160	03632
Ensembl ID		ENSG00000014138	ENSG00000067082
Uniprot IDs		Q14181	D3GC14 Q99612
PDB IDs		2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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