ARSA and CYB5R3

		ARSA	CYB5R3
Description		arylsulfatase A	cytochrome b5 reductase 3
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GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen
	Molecular Function	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding NAD Binding FAD Binding
	Biological Process	Glycosphingolipid Metabolic Process Neutrophil Degranulation	Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Blood Circulation L-ascorbic Acid Metabolic Process Neutrophil Degranulation Oxidation-reduction Process
Pathways		Glycosphingolipid metabolism The activation of arylsulfatases Neutrophil degranulation	Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		N,4-Dihydroxy-N-Oxo-3-(Sulfooxy)Benzenaminium 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid	NADH Flavin adenine dinucleotide Copper
Diseases		Metachromatic leukodystrophy (MLD)	Methemoglobinemia
GWAS		Blood metabolite levels ( 24816252) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) QT interval (ambient particulate matter interaction) ( 28749367) Urinary metabolite levels in chronic kidney disease ( 31959995) vWF and FVIII levels ( 30586737)	Initial pursuit acceleration ( 29064472)
Interacting Genes		8 interacting genes: BMPR2 CETN2 CLEC4G CTSL CYB5R3 GAL3ST1 PPIC TRIP13	11 interacting genes: ARSA CYB5A CYCS GAS1 HBG2 L3MBTL2 RPS6KB1 SBF1 SPP1 TUBGCP6 XPNPEP3
Entrez ID		410	1727
HPRD ID		09617	08942
Ensembl ID		ENSG00000100299	ENSG00000100243
Uniprot IDs		A0A0C4DFZ2 B4DVI5 P15289	P00387
PDB IDs		1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8	1M91 1UMK
Enriched GO Terms of Interacting Partners?
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