CYB5R3 and ARSA

		CYB5R3	ARSA
Description		cytochrome b5 reductase 3	arylsulfatase A
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen	Extracellular Region Lysosome Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding NAD Binding FAD Binding	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity
	Biological Process	Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Blood Circulation L-ascorbic Acid Metabolic Process Neutrophil Degranulation Oxidation-reduction Process	Glycosphingolipid Metabolic Process Neutrophil Degranulation
Pathways		Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation	Glycosphingolipid metabolism The activation of arylsulfatases Neutrophil degranulation
Drugs		NADH Flavin adenine dinucleotide Copper	N,4-Dihydroxy-N-Oxo-3-(Sulfooxy)Benzenaminium 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid
Diseases		Methemoglobinemia	Metachromatic leukodystrophy (MLD)
GWAS		Initial pursuit acceleration ( 29064472)	Blood metabolite levels ( 24816252) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) QT interval (ambient particulate matter interaction) ( 28749367) Urinary metabolite levels in chronic kidney disease ( 31959995) vWF and FVIII levels ( 30586737)
Interacting Genes		11 interacting genes: ARSA CYB5A CYCS GAS1 HBG2 L3MBTL2 RPS6KB1 SBF1 SPP1 TUBGCP6 XPNPEP3	8 interacting genes: BMPR2 CETN2 CLEC4G CTSL CYB5R3 GAL3ST1 PPIC TRIP13
Entrez ID		1727	410
HPRD ID		08942	09617
Ensembl ID		ENSG00000100243	ENSG00000100299
Uniprot IDs		P00387	A0A0C4DFZ2 B4DVI5 P15289
PDB IDs		1M91 1UMK	1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8
Enriched GO Terms of Interacting Partners?
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