ARSA and CTSL

Number of citations of the paper that reports this interaction (PubMedID 11777924)
4

Data Source:
HPRD (in vitro)

		ARSA	CTSL
Description		arylsulfatase A	cathepsin L
Image
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Plasma Membrane Endolysosome Lumen Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding
	Biological Process	Glycosphingolipid Metabolic Process Neutrophil Degranulation	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Collagen Catabolic Process Regulation Of Keratinocyte Differentiation Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Glycosphingolipid metabolism The activation of arylsulfatases Neutrophil degranulation	Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs		N,4-Dihydroxy-N-Oxo-3-(Sulfooxy)Benzenaminium 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid	Cysteinesulfonic Acid Felbinac
Diseases		Metachromatic leukodystrophy (MLD)
GWAS		Blood metabolite levels ( 24816252) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) QT interval (ambient particulate matter interaction) ( 28749367) Urinary metabolite levels in chronic kidney disease ( 31959995) vWF and FVIII levels ( 30586737)
Interacting Genes		8 interacting genes: BMPR2 CETN2 CLEC4G CTSL CYB5R3 GAL3ST1 PPIC TRIP13	28 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		410	1514
HPRD ID		09617	00293
Ensembl ID		ENSG00000100299	ENSG00000135047
Uniprot IDs		A0A0C4DFZ2 B4DVI5 P15289	A0A024R276 P07711 Q9HBQ7
PDB IDs		1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06
Enriched GO Terms of Interacting Partners?
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