CYB5R3 and CYCS

Number of citations of the paper that reports this interaction (PubMedID 4403130)
22

Data Source:
HPRD (in vitro)

		CYB5R3	CYCS
Description		cytochrome b5 reductase 3	cytochrome c, somatic
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respiratory Chain
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding NAD Binding FAD Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Heme Binding Electron Transporter, Transferring Electrons From CoQH2-cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity Metal Ion Binding
	Biological Process	Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Blood Circulation L-ascorbic Acid Metabolic Process Neutrophil Degranulation Oxidation-reduction Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Protein Dephosphorylation Apoptotic Process Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cellular Response To Oxidative Stress Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration
Pathways		Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation	Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs		NADH Flavin adenine dinucleotide Copper	Minocycline Protoporphyrin Ix Containing Co Heme C Imidazole Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C
Diseases		Methemoglobinemia	Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Initial pursuit acceleration ( 29064472)	Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)
Interacting Genes		11 interacting genes: ARSA CYB5A CYCS GAS1 HBG2 L3MBTL2 RPS6KB1 SBF1 SPP1 TUBGCP6 XPNPEP3	21 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2
Entrez ID		1727	54205
HPRD ID		08942	00479
Ensembl ID		ENSG00000100243	ENSG00000172115
Uniprot IDs		P00387	G4XXL9 P99999
PDB IDs		1M91 1UMK	1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ
Enriched GO Terms of Interacting Partners?
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