NEK8 and TRIM69

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NEK8	TRIM69
Description		NIMA related kinase 8	tripartite motif containing 69
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cilium Ciliary Inversin Compartment Ciliary Base	Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Chromosome Segregation Determination Of Left/right Symmetry Heart Development Animal Organ Morphogenesis Regulation Of Hippo Signaling	Protein Polyubiquitination Apoptotic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Reticulocyte count ( 27863252)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		6 interacting genes: ACVR1 NEK9 TCF4 TGFBR1 TRIM69 UBC	28 interacting genes: APP ASNS ATP5MC1 DVL1 FAM110A FKBP1B HAUS1 HGS IYD KRT17 LARP1B MAGEA4 NEK8 PML PPP1R18 RECK RSPH14 SF1 SF3A3 SKIL SYNE4 TRIM44 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N ZNF483
Entrez ID		284086	140691
HPRD ID		14822	11518
Ensembl ID		ENSG00000160602	ENSG00000185880
Uniprot IDs		Q86SG6	H0YL66 Q86WT6
PDB IDs			4NQJ
Enriched GO Terms of Interacting Partners?
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