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COL3A1 and PDGFB
Number of citations of the paper that reports this interaction (PubMedID
8900172
)
16
Data Source:
BioGRID
(pull down, far western blotting)
COL3A1
PDGFB
Description
collagen type III alpha 1 chain
platelet derived growth factor subunit B
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen Type III Trimer
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Golgi Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Lumen
Cell Surface
Basolateral Plasma Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Molecular Function
Protease Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
SMAD Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Superoxide-generating NADPH Oxidase Activator Activity
Chemoattractant Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Platelet-derived Growth Factor Binding
Growth Factor Receptor Binding
Biological Process
Skeletal System Development
Cell-matrix Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Heart Development
Response To Radiation
Response To Mechanical Stimulus
Peptide Cross-linking
Cerebral Cortex Development
Platelet Activation
Extracellular Matrix Organization
Collagen Fibril Organization
Response To Cytokine
Positive Regulation Of Rho Protein Signal Transduction
Wound Healing
Skin Development
Digestive Tract Development
Regulation Of Immune Response
Negative Regulation Of Immune Response
Aorta Smooth Muscle Tissue Morphogenesis
Cellular Response To Amino Acid Stimulus
Supramolecular Fiber Organization
Negative Regulation Of Neuron Migration
MAPK Cascade
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Monocyte Chemotaxis
Platelet Degranulation
Positive Regulation Of Glomerular Filtration
Protein Phosphorylation
Heart Development
Positive Regulation Of Cell Proliferation
Response To Wounding
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Activation Of Protein Kinase B Activity
Interleukin-18-mediated Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Paracrine Signaling
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Positive Regulation Of Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Cellular Response To Growth Factor Stimulus
Cellular Response To Mycophenolic Acid
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Metanephric Glomerular Mesangial Cell Development
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Smooth Muscle Cell Differentiation
Positive Regulation Of Vascular Smooth Muscle Cell Dedifferentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Pathways
Collagen degradation
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Collagenase clostridium histolyticum
Diseases
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
Malignant pleural mesothelioma
Glioma
GWAS
Parkinson disease and lewy body pathology (
25663231
)
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Interacting Genes
13 interacting genes:
CAPN1
DDR1
DDR2
FGF7
HTRA1
MAG
MYOC
PCOLCE
PDGFA
PDGFB
SPARC
THBS1
VWF
23 interacting genes:
A2M
ART1
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
FBXO7
HMOX1
HNRNPC
HRAS
HSPG2
LRP1
LYVE1
MDFI
PDAP1
PDGFRA
PDGFRB
PIK3R1
SPARC
THBS1
Entrez ID
1281
5155
HPRD ID
00365
01815
Ensembl ID
ENSG00000168542
ENSG00000100311
Uniprot IDs
P02461
A0A384NYY3
P01127
PDB IDs
2V53
3DMW
4AE2
4AEJ
4AK3
4GYX
6FZV
6FZW
1PDG
3MJG
4HQU
4HQX
4QCI
Enriched GO Terms of Interacting Partners
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