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PDGFB and MDFI
Number of citations of the paper that reports this interaction (PubMedID
19060904
)
283
Data Source:
BioGRID
(two hybrid)
PDGFB
MDFI
Description
platelet derived growth factor subunit B
MyoD family inhibitor
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Lumen
Cell Surface
Basolateral Plasma Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Nucleus
Cytoplasm
Molecular Function
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Superoxide-generating NADPH Oxidase Activator Activity
Chemoattractant Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Platelet-derived Growth Factor Binding
Growth Factor Receptor Binding
Protein Binding
Transcription Factor Binding
Identical Protein Binding
Biological Process
MAPK Cascade
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Monocyte Chemotaxis
Platelet Degranulation
Positive Regulation Of Glomerular Filtration
Protein Phosphorylation
Heart Development
Positive Regulation Of Cell Proliferation
Response To Wounding
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Activation Of Protein Kinase B Activity
Interleukin-18-mediated Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Paracrine Signaling
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Positive Regulation Of Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Cellular Response To Growth Factor Stimulus
Cellular Response To Mycophenolic Acid
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Metanephric Glomerular Mesangial Cell Development
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Smooth Muscle Cell Differentiation
Positive Regulation Of Vascular Smooth Muscle Cell Dedifferentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Negative Regulation Of Transcription By RNA Polymerase II
Dorsal/ventral Axis Specification
Negative Regulation Of Wnt Signaling Pathway
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of DNA Binding
Embryonic Skeletal System Morphogenesis
Trophoblast Giant Cell Differentiation
Pathways
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
Malignant pleural mesothelioma
Glioma
GWAS
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Grapefruit juice consumption (
31046077
)
Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) (
31557306
)
Interacting Genes
23 interacting genes:
A2M
ART1
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
FBXO7
HMOX1
HNRNPC
HRAS
HSPG2
LRP1
LYVE1
MDFI
PDAP1
PDGFRA
PDGFRB
PIK3R1
SPARC
THBS1
243 interacting genes:
AANAT
AASDHPPT
ABCF3
ABHD17A
ADAMTSL3
AKAP17A
AP5Z1
APLN
AQP1
AQP5
ARHGAP32
ARID5A
ATG12
ATN1
ATP6V0C
ATXN7L2
AVPI1
AXIN1
B3GNT9
BAALC
BAHD1
BANP
BBS2
BCL6
BEX1
C10orf62
C22orf39
C8orf33
C8orf48
CATSPER1
CBFA2T2
CBX2
CC2D1B
CCDC116
CCDC120
CCDC185
CCDC198
CCDC33
CCER1
CDC42EP1
CDCA7L
CDKL3
CEP57L1
CFAP206
CHIC2
CHRNG
CLPB
CNNM3
CREB5
CRX
CRY1
CSNK1G2-AS1
CXCL16
CYBA
DAAM2
DBF4B
DCAF8
DCANP1
DDX19A
DHRS1
DKK1
DMRT3
DNPEP
DOCK2
DUSP6
EBI3
EIF4A2
EIF4E2
ELOA
ENKD1
ETNK2
EWSR1
FAAP100
FAM124B
FAM161A
FAM27E3
FASTK
FBXL18
FBXO34
FBXW5
FES
FNDC11
FOXD4L6
FZD9
GATA1
GATA2
GDF15
GLIDR
GLRX3
GNAI2
GNG5
GPATCH2L
GPRIN2
GTF3C5
HEYL
HNRNPLL
HOXA1
HOXB9
HTR1B
ILF3
INTS11
IQUB
KANSL1
KAT5
KIAA0040
KIAA0408
KIF1A
KPNA2
KRAS
LAMB3
LASP1
LCE1B
LCE3E
LCE4A
LIMS2
LINC00636
LINC01588
LMO3
LRCH4
LRRN4
MACIR
MAGED1
MAGEF1
MAPKBP1
MCM5
MEOX2
METTL17
MFSD3
MGAT5B
MRPL20-AS1
MVP
MYF5
MYOD1
MYOG
NAB2
NDUFA7
NECTIN2
NEU4
NOL4L-DT
NPDC1
NR1H2
NR1H3
NTAQ1
ODAPH
OLIG3
OTX1
PARP11
PBXIP1
PDGFB
PDIA5
PGLS
PHLDA1
PID1
PIDD1
PIH1D2
PIN1
PLEKHG4
POM121L8P
PRKAB2
PRPF31
PTPMT1
RABL6
REG3A
REX1BD
RFX2
RIPPLY1
RNF6
RTP5
SERF2
SFI1
SHFL
SIX1
SLC25A10
SLC35A2
SLC9A1
SPATA3
SPATA8
SPG7
SPRY1
SPRY2
TAP1
TCF3
TEAD4
TGIF1
THAP7
THEG
TIE1
TINAGL1
TMEM241
TNNI1
TNP2
TRAF3IP2
TRIB3
TRPC1
TRPV6
TSC2
TTC23
TTC25
TTLL10
TUSC2
TYMSOS
TYRO3
USP20
USP6
VHL
VPS72
WDFY3
WNT11
ZBTB24
ZBTB25
ZBTB9
ZFYVE26
ZNF101
ZNF124
ZNF136
ZNF138
ZNF155
ZNF205
ZNF223
ZNF230
ZNF264
ZNF266
ZNF408
ZNF417
ZNF426
ZNF433
ZNF439
ZNF440
ZNF490
ZNF559
ZNF564
ZNF578
ZNF581
ZNF587
ZNF607
ZNF646
ZNF670
ZNF679
ZNF688
ZNF707
ZNF764
ZNF79
ZNF844
Entrez ID
5155
4188
HPRD ID
01815
07280
Ensembl ID
ENSG00000100311
ENSG00000112559
Uniprot IDs
A0A384NYY3
P01127
A0A024RCY2
B1AKB6
Q99750
PDB IDs
1PDG
3MJG
4HQU
4HQX
4QCI
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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