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PDGFB and THBS1
Number of citations of the paper that reports this interaction (PubMedID
9334164
)
11
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
PDGFB
THBS1
Description
platelet derived growth factor subunit B
thrombospondin 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Lumen
Cell Surface
Basolateral Plasma Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
External Side Of Plasma Membrane
Cell Surface
Sarcoplasmic Reticulum
Secretory Granule
Extracellular Matrix
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Superoxide-generating NADPH Oxidase Activator Activity
Chemoattractant Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Platelet-derived Growth Factor Binding
Growth Factor Receptor Binding
Phosphatidylserine Binding
Fibronectin Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Fibroblast Growth Factor Binding
Low-density Lipoprotein Particle Binding
Identical Protein Binding
Laminin Binding
Proteoglycan Binding
Transforming Growth Factor Beta Binding
Fibrinogen Binding
Collagen V Binding
Biological Process
MAPK Cascade
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Monocyte Chemotaxis
Platelet Degranulation
Positive Regulation Of Glomerular Filtration
Protein Phosphorylation
Heart Development
Positive Regulation Of Cell Proliferation
Response To Wounding
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Activation Of Protein Kinase B Activity
Interleukin-18-mediated Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Paracrine Signaling
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Positive Regulation Of Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Cellular Response To Growth Factor Stimulus
Cellular Response To Mycophenolic Acid
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Metanephric Glomerular Mesangial Cell Development
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Smooth Muscle Cell Differentiation
Positive Regulation Of Vascular Smooth Muscle Cell Dedifferentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Activation Of MAPK Activity
Response To Hypoxia
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Chronic Inflammatory Response
Platelet Degranulation
Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
Inflammatory Response
Immune Response
Response To Unfolded Protein
Cell Cycle Arrest
Cell Adhesion
Positive Regulation Of Cell Proliferation
Response To Mechanical Stimulus
Response To Glucose
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Negative Regulation Of Nitric Oxide Mediated Signal Transduction
Negative Regulation Of CGMP-mediated Signaling
Negative Regulation Of Plasminogen Activation
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Cell Migration
Negative Regulation Of Angiogenesis
Peptide Cross-linking
Positive Regulation Of Blood Coagulation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Magnesium Ion
Response To Progesterone
Negative Regulation Of Interleukin-12 Production
Positive Regulation Of Transforming Growth Factor Beta1 Production
Response To Testosterone
Cellular Response To Heat
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Response To Drug
Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Engulfment Of Apoptotic Cell
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Behavioral Response To Pain
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Chemotaxis
Response To Calcium Ion
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Fibrinolysis
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Endothelial Cell Chemotaxis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
Syndecan interactions
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
Malignant pleural mesothelioma
Glioma
GWAS
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Logical memory (immediate recall) in normal cognition (
29274321
)
Urate levels (
31578528
)
Interacting Genes
23 interacting genes:
A2M
ART1
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
FBXO7
HMOX1
HNRNPC
HRAS
HSPG2
LRP1
LYVE1
MDFI
PDAP1
PDGFRA
PDGFRB
PIK3R1
SPARC
THBS1
40 interacting genes:
CALCR
CALR
CD36
CD47
CFH
COL1A1
COL2A1
COL3A1
COL4A1
COL5A1
COL7A1
CORO1A
CTSG
DCN
DHFR
ELANE
F2
FGA
FGF2
FN1
HRG
IGFBP5
ITGB3
JAG1
KNG1
LAMB3
LRP1
LRP2
LRP5
MMP2
MMP9
MTDH
PDGFB
PLG
SCARB2
SPARC
TFPI
TGFB1
TNFAIP6
TNFRSF11B
Entrez ID
5155
7057
HPRD ID
01815
01765
Ensembl ID
ENSG00000100311
ENSG00000137801
Uniprot IDs
A0A384NYY3
P01127
P07996
PDB IDs
1PDG
3MJG
4HQU
4HQX
4QCI
1LSL
1UX6
1Z78
1ZA4
2ERF
2ES3
2OUH
2OUJ
3R6B
5FOE
Enriched GO Terms of Interacting Partners
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