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PDGFB and HNRNPC
Number of citations of the paper that reports this interaction (PubMedID
10409733
)
44
Data Source:
HPRD
(in vitro)
PDGFB
HNRNPC
Description
platelet derived growth factor subunit B
heterogeneous nuclear ribonucleoprotein C
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Lumen
Cell Surface
Basolateral Plasma Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Nuclear Chromatin
Extracellular Region
Nucleus
Nucleoplasm
Spliceosomal Complex
Telomerase Holoenzyme Complex
Cytosol
Actin Cytoskeleton
Membrane
Protein-containing Complex
Extracellular Exosome
Catalytic Step 2 Spliceosome
Molecular Function
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Superoxide-generating NADPH Oxidase Activator Activity
Chemoattractant Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Platelet-derived Growth Factor Binding
Growth Factor Receptor Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
Poly(U) RNA Binding
Nucleosomal DNA Binding
Identical Protein Binding
Telomerase RNA Binding
N6-methyladenosine-containing RNA Binding
Biological Process
MAPK Cascade
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Monocyte Chemotaxis
Platelet Degranulation
Positive Regulation Of Glomerular Filtration
Protein Phosphorylation
Heart Development
Positive Regulation Of Cell Proliferation
Response To Wounding
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Activation Of Protein Kinase B Activity
Interleukin-18-mediated Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Paracrine Signaling
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Positive Regulation Of Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Cellular Response To Growth Factor Stimulus
Cellular Response To Mycophenolic Acid
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Metanephric Glomerular Mesangial Cell Development
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Smooth Muscle Cell Differentiation
Positive Regulation Of Vascular Smooth Muscle Cell Dedifferentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Metanephric Mesenchymal Cell Migration
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
RNA Splicing
RNA Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
ATP-dependent Chromatin Remodeling
3'-UTR-mediated MRNA Stabilization
Pathways
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SUMOylation of RNA binding proteins
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
Malignant pleural mesothelioma
Glioma
GWAS
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Bipolar disorder (
31043756
21738484
)
Height (
31562340
)
Interacting Genes
23 interacting genes:
A2M
ART1
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
FBXO7
HMOX1
HNRNPC
HRAS
HSPG2
LRP1
LYVE1
MDFI
PDAP1
PDGFRA
PDGFRB
PIK3R1
SPARC
THBS1
51 interacting genes:
AP1M1
BARD1
BRCA1
BRCA2
BRIP1
BTRC
CCDC85B
CDKN2A
CELF1
CSNK1A1
CSNK2A1
CSNK2A2
DHX9
EPS8
ERG
ESR1
FAS
FXR2
GRB2
IL7R
KHDRBS3
KPNA2
KPNA3
KPNA4
KRAS
LMO2
LMO3
PALB2
PDGFB
PHKB
PIN1
PJA1
PRKDC
PTBP2
RAD51
RALY
RALYL
RBM41
SDCBP
SF3B2
SMARCD1
SREK1
SRPK2
SUMO1
SUMO1P1
TRAF3
UBE2I
YWHAE
YWHAQ
ZFYVE26
ZNF581
Entrez ID
5155
3183
HPRD ID
01815
01243
Ensembl ID
ENSG00000100311
ENSG00000092199
Uniprot IDs
A0A384NYY3
P01127
P07910
PDB IDs
1PDG
3MJG
4HQU
4HQX
4QCI
1TXP
1WF2
2MXY
2MZ1
3LN4
Enriched GO Terms of Interacting Partners
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