COL3A1 and FGF7

Number of citations of the paper that reports this interaction (PubMedID 11973338)
11

Data Source:
HPRD (in vitro)

		COL3A1	FGF7
Description		collagen type III alpha 1 chain	fibroblast growth factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Golgi Apparatus
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity
	Biological Process	Skeletal System Development Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Heart Development Response To Radiation Response To Mechanical Stimulus Peptide Cross-linking Cerebral Cortex Development Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Wound Healing Skin Development Digestive Tract Development Regulation Of Immune Response Negative Regulation Of Immune Response Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Supramolecular Fiber Organization Negative Regulation Of Neuron Migration	MAPK Cascade Signal Transduction Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Mesenchymal Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Hair Follicle Morphogenesis Actin Cytoskeleton Reorganization Protein Localization To Cell Surface Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization	PI3K Cascade PIP3 activates AKT signaling FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Collagenase clostridium histolyticum
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Parkinson disease and lewy body pathology ( 25663231)	Blood protein levels ( 30072576 29875488) Lung adenocarcinoma ( 28604730) Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)
Interacting Genes		13 interacting genes: CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1 VWF	14 interacting genes: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 PTX3 UBQLN1
Entrez ID		1281	2252
HPRD ID		00365	01022
Ensembl ID		ENSG00000168542	ENSG00000140285
Uniprot IDs		P02461	P21781
PDB IDs		2V53 3DMW 4AE2 4AEJ 4AK3 4GYX 6FZV 6FZW
Enriched GO Terms of Interacting Partners?
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