COL3A1 and PCOLCE

Number of citations of the paper that reports this interaction (PubMedID 12105202)
13

Data Source:
HPRD (in vitro)

		COL3A1	PCOLCE
Description		collagen type III alpha 1 chain	procollagen C-endopeptidase enhancer
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity
	Biological Process	Skeletal System Development Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Heart Development Response To Radiation Response To Mechanical Stimulus Peptide Cross-linking Cerebral Cortex Development Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Wound Healing Skin Development Digestive Tract Development Regulation Of Immune Response Negative Regulation Of Immune Response Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Supramolecular Fiber Organization Negative Regulation Of Neuron Migration	Proteolysis Multicellular Organism Development Positive Regulation Of Peptidase Activity Cellular Response To Leukemia Inhibitory Factor
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization	Collagen biosynthesis and modifying enzymes Crosslinking of collagen fibrils
Drugs		Collagenase clostridium histolyticum
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Parkinson disease and lewy body pathology ( 25663231)	Blood protein levels ( 30072576 29875488) Resting heart rate ( 27798624)
Interacting Genes		13 interacting genes: CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1 VWF	5 interacting genes: COL2A1 COL3A1 ECT2 HMGB1 PLG
Entrez ID		1281	5118
HPRD ID		00365	02603
Ensembl ID		ENSG00000168542	ENSG00000106333
Uniprot IDs		P02461	Q15113
PDB IDs		2V53 3DMW 4AE2 4AEJ 4AK3 4GYX 6FZV 6FZW	1UAP 6FZV 6FZW
Enriched GO Terms of Interacting Partners?
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