FBN2 - Wiki-Pi

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23 interactions involving FBN2 - fibrillin 2 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases

Novel	Symbol	Description	Pathways Hide	Drugs Hide	Diseases Hide
Novel	CMBL	carboxymethylenebutenolidase homolog	Phase I - Functionalization of compounds
Novel	CSF2	colony stimulating factor 2	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling	KB002
Novel	DPYSL5	dihydropyrimidinase like 5	CRMPs in Sema3A signaling
Novel	DUSP5	dual specificity phosphatase 5	RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
Novel	FDPS	farnesyl diphosphate synthase	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Pamidronic acid Zoledronic acid Alendronic acid Ibandronate Risedronic acid Dimethylallyl Diphosphate Isopentyl Pyrophosphate Geranyl Diphosphate ISOPENTENYL PYROPHOSPHATE Incadronic acid Minodronic acid Farnesyl diphosphate Geranylgeranyl diphosphate
Novel	ITGA2	integrin subunit alpha 2	Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans CHL1 interactions Platelet Adhesion to exposed collagen MET activates PTK2 signaling Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Novel	NDUFB6	NADH:ubiquinone oxidoreductase subunit B6	Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation	NADH
Novel	NRG2	neuregulin 2	Signaling by ERBB2 Signaling by ERBB4 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Novel	RNF14	ring finger protein 14	Antigen processing: Ubiquitination & Proteasome degradation
Novel	SEMA3F	semaphorin 3F
Novel	SIRPA	signal regulatory protein alpha	Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Novel	SLC27A6	solute carrier family 27 member 6	Transport of fatty acids
Novel	SNRPB	small nuclear ribonucleoprotein polypeptides B and B1	SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery
Novel	TRIM24	tripartite motif containing 24	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF1 fusions
Novel	UBE2B	ubiquitin conjugating enzyme E2 B	Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
	ELN	elastin	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Rofecoxib	Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Congenital supravalvar aortic stenosis
	FBN1	fibrillin 1	Degradation of the extracellular matrix Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation		Geleophysic dysplasia Weill-Marchesani syndrome, including: Weill-Marchesani syndrome; Weill-Marchesani-like syndrome Shprintzen-Goldberg syndrome Ectopia lentis MASS phenotype Marfan syndrome, including: Marfan syndrome (MFS); Neonatal MFS; Atypically severe MFS; New variant of MFS
	LTBP1	latent transforming growth factor beta binding protein 1	Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
	MATN2	matrilin 2
	MFAP2	microfibril associated protein 2	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres

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