Diabetes - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols NMI and CNKSR3	Name 1 N-myc and STAT interactor	Name2 CNKSR family member 3	Pathway 1 SARS-CoV-1 activates/modulates innate immune responses	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CDC23 and RSL24D1	Name 1 cell division cycle 23	Name2 ribosomal L24 domain containing 1	Pathway 1 Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2 (S)-3-phenyllactic acid Anisomycin Puromycin	Diseases 1	Diseases 2
Novel Novel	Symbols GABARAPL2 and BICC1	Name 1 GABA type A receptor associated protein like 2	Name2 BicC family RNA binding protein 1	Pathway 1 Macroautophagy TBC/RABGAPs	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols USO1 and YKT6	Name 1 USO1 vesicle transport factor	Name2 YKT6 vesicular SNARE protein	Pathway 1 Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport	Pathway 2 COPII-mediated vesicle transport COPI-mediated anterograde transport Intra-Golgi traffic RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TEAD4 and CCDC172	Name 1 TEA domain transcription factor 4	Name2 coiled-coil domain containing 172	Pathway 1 YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Zygotic genome activation (ZGA) Regulation of PD-L1(CD274) transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GRN and DLK1	Name 1 granulin precursor	Name2 delta like non-canonical Notch ligand 1	Pathway 1 Neutrophil degranulation	Pathway 2 Activated NOTCH1 Transmits Signal to the Nucleus	Drugs 1	Drugs 2	Diseases 1 Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)	Diseases 2
Novel Novel	Symbols PRKN and TOMM40	Name 1 parkin RBR E3 ubiquitin protein ligase	Name2 translocase of outer mitochondrial membrane 40	Pathway 1 PINK1-PRKN Mediated Mitophagy Regulation of necroptotic cell death Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 Mitochondrial protein import PINK1-PRKN Mediated Mitophagy	Drugs 1	Drugs 2	Diseases 1 Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols FHL3 and SLC44A3	Name 1 four and a half LIM domains 3	Name2 solute carrier family 44 member 3	Pathway 1	Pathway 2 Synthesis of PC SLC-mediated bile acid transport	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols STMN2 and CCDC85A	Name 1 stathmin 2	Name2 coiled-coil domain containing 85A	Pathway 1 RND1 GTPase cycle	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ACTN4 and INO80	Name 1 actinin alpha 4	Name2 INO80 complex ATPase subunit	Pathway 1 Platelet degranulation Nephrin family interactions	Pathway 2 UCH proteinases DNA Damage Recognition in GG-NER	Drugs 1	Drugs 2	Diseases 1 Nephrotic syndrome and focal segmental glomerulosclerosis	Diseases 2
Novel Novel	Symbols MEOX2 and IGF2BP3	Name 1 mesenchyme homeobox 2	Name2 insulin like growth factor 2 mRNA binding protein 3	Pathway 1	Pathway 2 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MEOX2 and MYL7	Name 1 mesenchyme homeobox 2	Name2 myosin light chain 7	Pathway 1	Pathway 2 Smooth Muscle Contraction	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MEOX2 and TEX14	Name 1 mesenchyme homeobox 2	Name2 testis expressed 14, intercellular bridge forming factor	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MEOX2 and STC1	Name 1 mesenchyme homeobox 2	Name2 stanniocalcin 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MEOX2 and FAM53B	Name 1 mesenchyme homeobox 2	Name2 family with sequence similarity 53 member B	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CALM2 and POC5	Name 1 calmodulin 2	Name2 POC5 centriolar protein	Pathway 1 CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity	Pathway 2	Drugs 1 Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine Dequalinium N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CALM2 and KCNQ3	Name 1 calmodulin 2	Name2 potassium voltage-gated channel subfamily Q member 3	Pathway 1 CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity	Pathway 2 Voltage gated Potassium channels Interaction between L1 and Ankyrins	Drugs 1 Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine Dequalinium N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate	Drugs 2 Enflurane Amitriptyline Meclofenamic acid Gabapentin Promethazine Miconazole Ezogabine ICA-105665	Diseases 1	Diseases 2
Novel Novel	Symbols CCNDBP1 and ZNF169	Name 1 cyclin D1 binding protein 1	Name2 zinc finger protein 169	Pathway 1	Pathway 2 Generic Transcription Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PITPNC1 and AGTRAP	Name 1 phosphatidylinositol transfer protein cytoplasmic 1	Name2 angiotensin II receptor associated protein	Pathway 1	Pathway 2 Signaling by BRAF and RAF1 fusions	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HPCAL1 and DTX2	Name 1 hippocalcin like 1	Name2 deltex E3 ubiquitin ligase 2	Pathway 1	Pathway 2 Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NMI and CNKSR3	Name 1 N-myc and STAT interactor	Name2 CNKSR family member 3	Pathway 1 SARS-CoV-1 activates/modulates innate immune responses	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CDC23 and RSL24D1	Name 1 cell division cycle 23	Name2 ribosomal L24 domain containing 1	Pathway 1 Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2 (S)-3-phenyllactic acid Anisomycin Puromycin	Diseases 1	Diseases 2
Novel	Symbols GABARAPL2 and BICC1	Name 1 GABA type A receptor associated protein like 2	Name2 BicC family RNA binding protein 1	Pathway 1 Macroautophagy TBC/RABGAPs	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols USO1 and YKT6	Name 1 USO1 vesicle transport factor	Name2 YKT6 vesicular SNARE protein	Pathway 1 Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport	Pathway 2 COPII-mediated vesicle transport COPI-mediated anterograde transport Intra-Golgi traffic RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TEAD4 and CCDC172	Name 1 TEA domain transcription factor 4	Name2 coiled-coil domain containing 172	Pathway 1 YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Zygotic genome activation (ZGA) Regulation of PD-L1(CD274) transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GRN and DLK1	Name 1 granulin precursor	Name2 delta like non-canonical Notch ligand 1	Pathway 1 Neutrophil degranulation	Pathway 2 Activated NOTCH1 Transmits Signal to the Nucleus	Drugs 1	Drugs 2	Diseases 1 Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)	Diseases 2
Novel	Symbols PRKN and TOMM40	Name 1 parkin RBR E3 ubiquitin protein ligase	Name2 translocase of outer mitochondrial membrane 40	Pathway 1 PINK1-PRKN Mediated Mitophagy Regulation of necroptotic cell death Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 Mitochondrial protein import PINK1-PRKN Mediated Mitophagy	Drugs 1	Drugs 2	Diseases 1 Parkinson's disease (PD)	Diseases 2
Novel	Symbols FHL3 and SLC44A3	Name 1 four and a half LIM domains 3	Name2 solute carrier family 44 member 3	Pathway 1	Pathway 2 Synthesis of PC SLC-mediated bile acid transport	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols STMN2 and CCDC85A	Name 1 stathmin 2	Name2 coiled-coil domain containing 85A	Pathway 1 RND1 GTPase cycle	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ACTN4 and INO80	Name 1 actinin alpha 4	Name2 INO80 complex ATPase subunit	Pathway 1 Platelet degranulation Nephrin family interactions	Pathway 2 UCH proteinases DNA Damage Recognition in GG-NER	Drugs 1	Drugs 2	Diseases 1 Nephrotic syndrome and focal segmental glomerulosclerosis	Diseases 2
Novel	Symbols MEOX2 and IGF2BP3	Name 1 mesenchyme homeobox 2	Name2 insulin like growth factor 2 mRNA binding protein 3	Pathway 1	Pathway 2 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MEOX2 and MYL7	Name 1 mesenchyme homeobox 2	Name2 myosin light chain 7	Pathway 1	Pathway 2 Smooth Muscle Contraction	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MEOX2 and TEX14	Name 1 mesenchyme homeobox 2	Name2 testis expressed 14, intercellular bridge forming factor	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MEOX2 and STC1	Name 1 mesenchyme homeobox 2	Name2 stanniocalcin 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MEOX2 and FAM53B	Name 1 mesenchyme homeobox 2	Name2 family with sequence similarity 53 member B	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CALM2 and POC5	Name 1 calmodulin 2	Name2 POC5 centriolar protein	Pathway 1 CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity	Pathway 2	Drugs 1 Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine Dequalinium N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CALM2 and KCNQ3	Name 1 calmodulin 2	Name2 potassium voltage-gated channel subfamily Q member 3	Pathway 1 CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity	Pathway 2 Voltage gated Potassium channels Interaction between L1 and Ankyrins	Drugs 1 Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine Dequalinium N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate	Drugs 2 Enflurane Amitriptyline Meclofenamic acid Gabapentin Promethazine Miconazole Ezogabine ICA-105665	Diseases 1	Diseases 2
Novel	Symbols CCNDBP1 and ZNF169	Name 1 cyclin D1 binding protein 1	Name2 zinc finger protein 169	Pathway 1	Pathway 2 Generic Transcription Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PITPNC1 and AGTRAP	Name 1 phosphatidylinositol transfer protein cytoplasmic 1	Name2 angiotensin II receptor associated protein	Pathway 1	Pathway 2 Signaling by BRAF and RAF1 fusions	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HPCAL1 and DTX2	Name 1 hippocalcin like 1	Name2 deltex E3 ubiquitin ligase 2	Pathway 1	Pathway 2 Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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