Diabetes - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols PTK2B and PITPNM2	Name 1 protein tyrosine kinase 2 beta	Name2 phosphatidylinositol transfer protein membrane associated 2	Pathway 1 Signal regulatory protein family interactions VEGFA-VEGFR2 Pathway RHOU GTPase cycle Interleukin-2 signaling	Pathway 2 Synthesis of PI	Drugs 1 Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols YWHAZ and MPHOSPH9	Name 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Name2 M-phase phosphoprotein 9	Pathway 1 Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2	Drugs 1 Phenethyl Isothiocyanate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols YWHAZ and CGNL1	Name 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Name2 cingulin like 1	Pathway 1 Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2	Drugs 1 Phenethyl Isothiocyanate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HNRNPD and IMMP2L	Name 1 heterogeneous nuclear ribonucleoprotein D	Name2 inner mitochondrial membrane peptidase subunit 2	Pathway 1 mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Pathway 2	Drugs 1 Artenimol	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TSG101 and SNF8	Name 1 tumor susceptibility 101	Name2 SNF8 subunit of ESCRT-II	Pathway 1 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Pathway 2 Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TSG101 and CCDC88B	Name 1 tumor susceptibility 101	Name2 coiled-coil and HOOK domain protein 88B	Pathway 1 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PGR and BATF3	Name 1 progesterone receptor	Name2 basic leucine zipper ATF-like transcription factor 3	Pathway 1 Nuclear signaling by ERBB4 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	Pathway 2	Drugs 1 Etonogestrel Desogestrel Megestrol acetate Levonorgestrel Dydrogesterone Progesterone Spironolactone Lindane Fluticasone propionate Medroxyprogesterone acetate Mitotane Norethisterone Mometasone Ethynodiol diacetate Mifepristone Norgestimate Drospirenone Danazol Oxybenzone Allylestrenol Phthalic Acid Metribolone Tanaproget Telapristone acetate Asoprisnil Norelgestromin Gestodene Hydroxyprogesterone caproate Ulipristal Fluticasone furoate Dienogest Medrogestone Norgestrel Homosalate Enzacamene Gestrinone Darolutamide Demegestone Fluticasone Mometasone furoate Segesterone acetate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PSMD4 and TMEM129	Name 1 proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Name2 transmembrane protein 129, E3 ubiquitin ligase	Pathway 1 Proteasome assembly Proteasome assembly	Pathway 2 E3 ubiquitin ligases ubiquitinate target proteins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GTF2I and PRRX1	Name 1 general transcription factor IIi	Name2 paired related homeobox 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRAF1 and TBX18	Name 1 TNF receptor associated factor 1	Name2 T-box transcription factor 18	Pathway 1 Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRAF1 and TNFRSF19	Name 1 TNF receptor associated factor 1	Name2 TNF receptor superfamily member 19	Pathway 1 Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CUL5 and RHOBTB1	Name 1 cullin 5	Name2 Rho related BTB domain containing 1	Pathway 1 Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses	Pathway 2 RHOBTB1 GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PEX7 and PEX5L	Name 1 peroxisomal biogenesis factor 7	Name2 peroxisomal biogenesis factor 5 like	Pathway 1 Peroxisomal protein import Peroxisomal protein import	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Refsum disease; Heredopathia atactica polyneuritiformis Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	Diseases 2
Novel Novel	Symbols TRAF2 and FAM120B	Name 1 TNF receptor associated factor 2	Name2 family with sequence similarity 120 member B	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2 PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRAF2 and AASDHPPT	Name 1 TNF receptor associated factor 2	Name2 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2 Vitamin B5 (pantothenate) metabolism	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRAF2 and TRIM31	Name 1 TNF receptor associated factor 2	Name2 tripartite motif containing 31	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2 Interferon gamma signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRAF2 and MBLAC1	Name 1 TNF receptor associated factor 2	Name2 metallo-beta-lactamase domain containing 1	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRAF2 and TNFSF4	Name 1 TNF receptor associated factor 2	Name2 TNF superfamily member 4	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2 TNFs bind their physiological receptors	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RING1 and PCGF3	Name 1 ring finger protein 1	Name2 polycomb group ring finger 3	Pathway 1 Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RAC1 and FAM13A	Name 1 Rac family small GTPase 1	Name2 family with sequence similarity 13 member A	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 RAC1 GTPase cycle NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Azathioprine ADME Factors involved in megakaryocyte development and platelet production	Pathway 2 RHOA GTPase cycle RAC1 GTPase cycle	Drugs 1 Dextromethorphan Azathioprine Guanosine-5'-Diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PTK2B and PITPNM2	Name 1 protein tyrosine kinase 2 beta	Name2 phosphatidylinositol transfer protein membrane associated 2	Pathway 1 Signal regulatory protein family interactions VEGFA-VEGFR2 Pathway RHOU GTPase cycle Interleukin-2 signaling	Pathway 2 Synthesis of PI	Drugs 1 Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols YWHAZ and MPHOSPH9	Name 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Name2 M-phase phosphoprotein 9	Pathway 1 Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2	Drugs 1 Phenethyl Isothiocyanate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols YWHAZ and CGNL1	Name 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Name2 cingulin like 1	Pathway 1 Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2	Drugs 1 Phenethyl Isothiocyanate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HNRNPD and IMMP2L	Name 1 heterogeneous nuclear ribonucleoprotein D	Name2 inner mitochondrial membrane peptidase subunit 2	Pathway 1 mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Pathway 2	Drugs 1 Artenimol	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TSG101 and SNF8	Name 1 tumor susceptibility 101	Name2 SNF8 subunit of ESCRT-II	Pathway 1 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Pathway 2 Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TSG101 and CCDC88B	Name 1 tumor susceptibility 101	Name2 coiled-coil and HOOK domain protein 88B	Pathway 1 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PGR and BATF3	Name 1 progesterone receptor	Name2 basic leucine zipper ATF-like transcription factor 3	Pathway 1 Nuclear signaling by ERBB4 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	Pathway 2	Drugs 1 Etonogestrel Desogestrel Megestrol acetate Levonorgestrel Dydrogesterone Progesterone Spironolactone Lindane Fluticasone propionate Medroxyprogesterone acetate Mitotane Norethisterone Mometasone Ethynodiol diacetate Mifepristone Norgestimate Drospirenone Danazol Oxybenzone Allylestrenol Phthalic Acid Metribolone Tanaproget Telapristone acetate Asoprisnil Norelgestromin Gestodene Hydroxyprogesterone caproate Ulipristal Fluticasone furoate Dienogest Medrogestone Norgestrel Homosalate Enzacamene Gestrinone Darolutamide Demegestone Fluticasone Mometasone furoate Segesterone acetate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PSMD4 and TMEM129	Name 1 proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Name2 transmembrane protein 129, E3 ubiquitin ligase	Pathway 1 Proteasome assembly Proteasome assembly	Pathway 2 E3 ubiquitin ligases ubiquitinate target proteins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GTF2I and PRRX1	Name 1 general transcription factor IIi	Name2 paired related homeobox 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRAF1 and TBX18	Name 1 TNF receptor associated factor 1	Name2 T-box transcription factor 18	Pathway 1 Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRAF1 and TNFRSF19	Name 1 TNF receptor associated factor 1	Name2 TNF receptor superfamily member 19	Pathway 1 Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CUL5 and RHOBTB1	Name 1 cullin 5	Name2 Rho related BTB domain containing 1	Pathway 1 Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses	Pathway 2 RHOBTB1 GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PEX7 and PEX5L	Name 1 peroxisomal biogenesis factor 7	Name2 peroxisomal biogenesis factor 5 like	Pathway 1 Peroxisomal protein import Peroxisomal protein import	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Refsum disease; Heredopathia atactica polyneuritiformis Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	Diseases 2
Novel	Symbols TRAF2 and FAM120B	Name 1 TNF receptor associated factor 2	Name2 family with sequence similarity 120 member B	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2 PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRAF2 and AASDHPPT	Name 1 TNF receptor associated factor 2	Name2 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2 Vitamin B5 (pantothenate) metabolism	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRAF2 and TRIM31	Name 1 TNF receptor associated factor 2	Name2 tripartite motif containing 31	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2 Interferon gamma signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRAF2 and MBLAC1	Name 1 TNF receptor associated factor 2	Name2 metallo-beta-lactamase domain containing 1	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRAF2 and TNFSF4	Name 1 TNF receptor associated factor 2	Name2 TNF superfamily member 4	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2 TNFs bind their physiological receptors	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RING1 and PCGF3	Name 1 ring finger protein 1	Name2 polycomb group ring finger 3	Pathway 1 Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RAC1 and FAM13A	Name 1 Rac family small GTPase 1	Name2 family with sequence similarity 13 member A	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 RAC1 GTPase cycle NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Azathioprine ADME Factors involved in megakaryocyte development and platelet production	Pathway 2 RHOA GTPase cycle RAC1 GTPase cycle	Drugs 1 Dextromethorphan Azathioprine Guanosine-5'-Diphosphate	Drugs 2	Diseases 1	Diseases 2

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