PCNT - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NIPBL	NIPBL cohesin loading factor	Cohesin Loading onto Chromatin		Cornelia de Lange syndrome (CdLS)
ODF2L	outer dense fiber of sperm tails 2 like
PARVB	parvin beta	Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PCM1	pericentriolar material 1	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
PNISR	PNN interacting serine and arginine rich protein
RPRD1A	regulation of nuclear pre-mRNA domain containing 1A	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
RRBP1	ribosome binding protein 1	Signaling by ALK fusions and activated point mutants	Radezolid
RTRAF	RNA transcription, translation and transport factor	tRNA processing in the nucleus
SEPTIN7	septin 7	MAPK6/MAPK4 signaling
SHTN1	shootin 1	Recycling pathway of L1
SPTAN1	spectrin alpha, non-erythrocytic 1	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea		Early infantile epileptic encephalopathy; Ohtahara syndrome
SPTBN1	spectrin beta, non-erythrocytic 1	Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	Calcium 1D-myo-inositol 1,4,5-trisphosphate
SPTBN2	spectrin beta, non-erythrocytic 2	MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
ST18	ST18 C2H2C-type zinc finger transcription factor
SYNE1	spectrin repeat containing nuclear envelope protein 1	Meiotic synapsis		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Emery-Dreifuss muscular dystrophy
TP53BP1	tumor protein p53 binding protein 1	SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
TRAF3IP1	TRAF3 interacting protein 1	Intraflagellar transport Intraflagellar transport
TUBG1	tubulin gamma 1	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Vinblastine
TUBGCP2	tubulin gamma complex component 2	Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes

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