HIV - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols DRD2 and WLS	Name 1 dopamine receptor D2	Name2 Wnt ligand secretion mediator	Pathway 1 Dopamine receptors	Pathway 2 WNT ligand biogenesis and trafficking	Drugs 1 Amphetamine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Imipramine Chlorpromazine Buspirone Haloperidol Triflupromazine Nortriptyline Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupentixol Amantadine Mesoridazine Maprotiline Dopamine Carphenazine Memantine Ergoloid mesylate Acetophenazine Promethazine Pimozide Desipramine Escitalopram Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Brasofensine Bifeprunox Bicifadine Itopride Iloperidone Rotigotine BL-1020 Norclozapine Amitifadine Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Asenapine Ocaperidone Amisulpride Sarizotan Sumanirole Nandrolone decanoate Lurasidone Perospirone Bromopride Quinagolide Brexpiprazole Etoperidone AS-8112 Blonanserin Melperone Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Tetrahydropalmatine Piribedil Raclopride JNJ-37822681 Tiapride Dihydroergocristine Aripiprazole lauroxil	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MMP9 and THBS2	Name 1 matrix metallopeptidase 9	Name2 thrombospondin 2	Pathway 1 Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling	Pathway 2 Signaling by PDGF Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Drugs 1 Glutathione Marimastat Minocycline Captopril Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Oleandrin Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Drugs 2	Diseases 1 Penile cancer Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)	Diseases 2
Novel Novel	Symbols HLA-DMB and HLA-DRA	Name 1 major histocompatibility complex, class II, DM beta	Name2 major histocompatibility complex, class II, DR alpha	Pathway 1 MHC class II antigen presentation	Pathway 2 Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling	Drugs 1	Drugs 2 1D09C3 Coccidioides immitis spherule	Diseases 1	Diseases 2
Novel Novel	Symbols HSPA1A and MSR1	Name 1 heat shock protein family A (Hsp70) member 1A	Name2 macrophage scavenger receptor 1	Pathway 1 Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt) Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt)	Pathway 2 Scavenging by Class A Receptors Scavenging by Class A Receptors	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CLK1 and FAT1	Name 1 CDC like kinase 1	Name2 FAT atypical cadherin 1	Pathway 1	Pathway 2	Drugs 1 Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CLK1 and HTATSF1	Name 1 CDC like kinase 1	Name2 HIV-1 Tat specific factor 1	Pathway 1	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1 Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SMAD1 and MAST4	Name 1 SMAD family member 1	Name2 microtubule associated serine/threonine kinase family member 4	Pathway 1 Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development Cardiogenesis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols STX2 and STXBP5L	Name 1 syntaxin 2	Name2 syntaxin binding protein 5L	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols F3 and F7	Name 1 coagulation factor III, tissue factor	Name2 coagulation factor VII	Pathway 1 Extrinsic Pathway of Fibrin Clot Formation NGF-stimulated transcription	Pathway 2 BMAL1:CLOCK,NPAS2 activates circadian expression Extrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins	Drugs 1 IIa Recombinant Human rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Coagulation factor VII human Tisotumab vedotin	Drugs 2 IIa Recombinant Human Coagulation Factor IX (Recombinant) (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Kappadione Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol	Diseases 1	Diseases 2
Novel Novel	Symbols ETS1 and HTATIP2	Name 1 ETS proto-oncogene 1, transcription factor	Name2 HIV-1 Tat interactive protein 2	Pathway 1 Oncogene Induced Senescence	Pathway 2	Drugs 1	Drugs 2 Polyethylene glycol 400	Diseases 1	Diseases 2
Novel Novel	Symbols SUPT5H and HTATSF1	Name 1 SPT5 homolog, DSIF elongation factor subunit	Name2 HIV-1 Tat specific factor 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SUPT4H1 and HTATSF1	Name 1 SPT4 homolog, DSIF elongation factor subunit	Name2 HIV-1 Tat specific factor 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PLN and PLPPR1	Name 1 phospholamban	Name2 phospholipid phosphatase related 1	Pathway 1 Ion homeostasis Ion transport by P-type ATPases	Pathway 2 Lysosphingolipid and LPA receptors	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols KLF9 and PGR	Name 1 KLF transcription factor 9	Name2 progesterone receptor	Pathway 1 Positive Regulation of CDH1 Gene Transcription	Pathway 2 Nuclear signaling by ERBB4 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	Drugs 1	Drugs 2 Etonogestrel Desogestrel Megestrol acetate Levonorgestrel Dydrogesterone Progesterone Spironolactone Lindane Fluticasone propionate Medroxyprogesterone acetate Mitotane Norethisterone Mometasone Ethynodiol diacetate Mifepristone Norgestimate Drospirenone Danazol Oxybenzone Allylestrenol Phthalic Acid Metribolone Tanaproget Telapristone acetate Asoprisnil Norelgestromin Gestodene Hydroxyprogesterone caproate Ulipristal Fluticasone furoate Dienogest Medrogestone Norgestrel Homosalate Enzacamene Gestrinone Darolutamide Demegestone Fluticasone Mometasone furoate Segesterone acetate	Diseases 1	Diseases 2
Novel Novel	Symbols PTEN and ABCF2	Name 1 phosphatase and tensin homolog	Name2 ATP binding cassette subfamily F member 2	Pathway 1 Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Negative regulation of the PI3K/AKT network Downstream TCR signaling TP53 Regulates Metabolic Genes PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2	Pathway 2 NFE2L2 regulating MDR associated enzymes	Drugs 1 Phosphatidylethanolamine	Drugs 2	Diseases 1 Vulvar cancer Breast cancer Malignant melanoma Prostate cancer Hepatocellular carcinoma Small cell lung cancer Endometrial Cancer Glioma	Diseases 2
Novel Novel	Symbols HDAC6 and HTATSF1	Name 1 histone deacetylase 6	Name2 HIV-1 Tat specific factor 1	Pathway 1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cargo trafficking to the periciliary membrane Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1 Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HDAC6 and HTATIP2	Name 1 histone deacetylase 6	Name2 HIV-1 Tat interactive protein 2	Pathway 1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cargo trafficking to the periciliary membrane Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Pathway 2	Drugs 1 Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac	Drugs 2 Polyethylene glycol 400	Diseases 1	Diseases 2
Novel Novel	Symbols DDR1 and SNRNP40	Name 1 discoidin domain receptor tyrosine kinase 1	Name2 small nuclear ribonucleoprotein U5 subunit 40	Pathway 1 Non-integrin membrane-ECM interactions	Pathway 2 mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Drugs 1 Imatinib Fostamatinib Pralsetinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SUMO2 and WDHD1	Name 1 small ubiquitin like modifier 2	Name2 WD repeat and HMG-box DNA binding protein 1	Pathway 1 Vitamin D (calciferol) metabolism SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Regulation of endogenous retroelements by KRAB-ZFP proteins	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CDH10 and COPS6	Name 1 cadherin 10	Name2 COP9 signalosome subunit 6	Pathway 1 Adherens junctions interactions	Pathway 2 DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols DRD2 and WLS	Name 1 dopamine receptor D2	Name2 Wnt ligand secretion mediator	Pathway 1 Dopamine receptors	Pathway 2 WNT ligand biogenesis and trafficking	Drugs 1 Amphetamine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Imipramine Chlorpromazine Buspirone Haloperidol Triflupromazine Nortriptyline Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupentixol Amantadine Mesoridazine Maprotiline Dopamine Carphenazine Memantine Ergoloid mesylate Acetophenazine Promethazine Pimozide Desipramine Escitalopram Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Brasofensine Bifeprunox Bicifadine Itopride Iloperidone Rotigotine BL-1020 Norclozapine Amitifadine Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Asenapine Ocaperidone Amisulpride Sarizotan Sumanirole Nandrolone decanoate Lurasidone Perospirone Bromopride Quinagolide Brexpiprazole Etoperidone AS-8112 Blonanserin Melperone Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Tetrahydropalmatine Piribedil Raclopride JNJ-37822681 Tiapride Dihydroergocristine Aripiprazole lauroxil	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MMP9 and THBS2	Name 1 matrix metallopeptidase 9	Name2 thrombospondin 2	Pathway 1 Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling	Pathway 2 Signaling by PDGF Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Drugs 1 Glutathione Marimastat Minocycline Captopril Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Oleandrin Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Drugs 2	Diseases 1 Penile cancer Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)	Diseases 2
Novel	Symbols HLA-DMB and HLA-DRA	Name 1 major histocompatibility complex, class II, DM beta	Name2 major histocompatibility complex, class II, DR alpha	Pathway 1 MHC class II antigen presentation	Pathway 2 Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling	Drugs 1	Drugs 2 1D09C3 Coccidioides immitis spherule	Diseases 1	Diseases 2
Novel	Symbols HSPA1A and MSR1	Name 1 heat shock protein family A (Hsp70) member 1A	Name2 macrophage scavenger receptor 1	Pathway 1 Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt) Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt)	Pathway 2 Scavenging by Class A Receptors Scavenging by Class A Receptors	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CLK1 and FAT1	Name 1 CDC like kinase 1	Name2 FAT atypical cadherin 1	Pathway 1	Pathway 2	Drugs 1 Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CLK1 and HTATSF1	Name 1 CDC like kinase 1	Name2 HIV-1 Tat specific factor 1	Pathway 1	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1 Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SMAD1 and MAST4	Name 1 SMAD family member 1	Name2 microtubule associated serine/threonine kinase family member 4	Pathway 1 Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development Cardiogenesis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols STX2 and STXBP5L	Name 1 syntaxin 2	Name2 syntaxin binding protein 5L	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols F3 and F7	Name 1 coagulation factor III, tissue factor	Name2 coagulation factor VII	Pathway 1 Extrinsic Pathway of Fibrin Clot Formation NGF-stimulated transcription	Pathway 2 BMAL1:CLOCK,NPAS2 activates circadian expression Extrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins	Drugs 1 IIa Recombinant Human rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Coagulation factor VII human Tisotumab vedotin	Drugs 2 IIa Recombinant Human Coagulation Factor IX (Recombinant) (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Kappadione Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol	Diseases 1	Diseases 2
Novel	Symbols ETS1 and HTATIP2	Name 1 ETS proto-oncogene 1, transcription factor	Name2 HIV-1 Tat interactive protein 2	Pathway 1 Oncogene Induced Senescence	Pathway 2	Drugs 1	Drugs 2 Polyethylene glycol 400	Diseases 1	Diseases 2
Novel	Symbols SUPT5H and HTATSF1	Name 1 SPT5 homolog, DSIF elongation factor subunit	Name2 HIV-1 Tat specific factor 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SUPT4H1 and HTATSF1	Name 1 SPT4 homolog, DSIF elongation factor subunit	Name2 HIV-1 Tat specific factor 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PLN and PLPPR1	Name 1 phospholamban	Name2 phospholipid phosphatase related 1	Pathway 1 Ion homeostasis Ion transport by P-type ATPases	Pathway 2 Lysosphingolipid and LPA receptors	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols KLF9 and PGR	Name 1 KLF transcription factor 9	Name2 progesterone receptor	Pathway 1 Positive Regulation of CDH1 Gene Transcription	Pathway 2 Nuclear signaling by ERBB4 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	Drugs 1	Drugs 2 Etonogestrel Desogestrel Megestrol acetate Levonorgestrel Dydrogesterone Progesterone Spironolactone Lindane Fluticasone propionate Medroxyprogesterone acetate Mitotane Norethisterone Mometasone Ethynodiol diacetate Mifepristone Norgestimate Drospirenone Danazol Oxybenzone Allylestrenol Phthalic Acid Metribolone Tanaproget Telapristone acetate Asoprisnil Norelgestromin Gestodene Hydroxyprogesterone caproate Ulipristal Fluticasone furoate Dienogest Medrogestone Norgestrel Homosalate Enzacamene Gestrinone Darolutamide Demegestone Fluticasone Mometasone furoate Segesterone acetate	Diseases 1	Diseases 2
Novel	Symbols PTEN and ABCF2	Name 1 phosphatase and tensin homolog	Name2 ATP binding cassette subfamily F member 2	Pathway 1 Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Negative regulation of the PI3K/AKT network Downstream TCR signaling TP53 Regulates Metabolic Genes PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2	Pathway 2 NFE2L2 regulating MDR associated enzymes	Drugs 1 Phosphatidylethanolamine	Drugs 2	Diseases 1 Vulvar cancer Breast cancer Malignant melanoma Prostate cancer Hepatocellular carcinoma Small cell lung cancer Endometrial Cancer Glioma	Diseases 2
Novel	Symbols HDAC6 and HTATSF1	Name 1 histone deacetylase 6	Name2 HIV-1 Tat specific factor 1	Pathway 1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cargo trafficking to the periciliary membrane Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1 Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HDAC6 and HTATIP2	Name 1 histone deacetylase 6	Name2 HIV-1 Tat interactive protein 2	Pathway 1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cargo trafficking to the periciliary membrane Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Pathway 2	Drugs 1 Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac	Drugs 2 Polyethylene glycol 400	Diseases 1	Diseases 2
Novel	Symbols DDR1 and SNRNP40	Name 1 discoidin domain receptor tyrosine kinase 1	Name2 small nuclear ribonucleoprotein U5 subunit 40	Pathway 1 Non-integrin membrane-ECM interactions	Pathway 2 mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Drugs 1 Imatinib Fostamatinib Pralsetinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SUMO2 and WDHD1	Name 1 small ubiquitin like modifier 2	Name2 WD repeat and HMG-box DNA binding protein 1	Pathway 1 Vitamin D (calciferol) metabolism SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Regulation of endogenous retroelements by KRAB-ZFP proteins	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CDH10 and COPS6	Name 1 cadherin 10	Name2 COP9 signalosome subunit 6	Pathway 1 Adherens junctions interactions	Pathway 2 DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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