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FGFR3
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fibroblast growth factor receptor 3 |
- Signaling by activated point mutants of FGFR3
- t(4;14) translocations of FGFR3
- Signaling by FGFR3 in disease
- Signaling by FGFR3 fusions in cancer
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- XL999
- Pazopanib
- Ponatinib
- Lenvatinib
- Nintedanib
- Infigratinib
- Fostamatinib
- Erdafitinib
- Pemigatinib
- Futibatinib
- Selpercatinib
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- CATSHL syndrome
- Multiple myeloma
- FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN)
- Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
- Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
- Bladder cancer
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FRZB
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frizzled related protein |
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HDAC6
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histone deacetylase 6 |
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- HSF1 activation
- Notch-HLH transcription pathway
- Cargo trafficking to the periciliary membrane
- Transcriptional regulation by RUNX2
- RUNX2 regulates osteoblast differentiation
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Aggrephagy
- Aggrephagy
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- Valproic acid
- Decitabine
- Vorinostat
- Vorinostat
- Belinostat
- Pracinostat
- Romidepsin
- Romidepsin
- Panobinostat
- Phenylbutyric acid
- Entinostat
- Abexinostat
- Givinostat
- Pyroxamide
- Bufexamac
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HELB
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DNA helicase B |
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HGH1
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HGH1 cochaperone |
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IGFBP3
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insulin like growth factor binding protein 3 |
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- TP53 Regulates Transcription of Death Receptors and Ligands
- Post-translational protein phosphorylation
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KCNE3
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potassium voltage-gated channel subfamily E regulatory subunit 3 |
- Phase 3 - rapid repolarisation
- Phase 2 - plateau phase
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- Enflurane
- Promethazine
- Miconazole
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KLF6
|
KLF transcription factor 6 |
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LRPAP1
|
LDL receptor related protein associated protein 1 |
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MFHAS1
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multifunctional ROCO family signaling regulator 1 |
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NR4A1
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nuclear receptor subfamily 4 group A member 1 |
- AKT phosphorylates targets in the nucleus
- Nuclear Receptor transcription pathway
- Constitutive Signaling by AKT1 E17K in Cancer
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PARP1
|
poly(ADP-ribose) polymerase 1 |
- POLB-Dependent Long Patch Base Excision Repair
- vRNA Synthesis
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SUMOylation of DNA damage response and repair proteins
- HDR through MMEJ (alt-NHEJ)
- DNA Damage Recognition in GG-NER
- Formation of Incision Complex in GG-NER
- Dual Incision in GG-NER
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- Theophylline
- Zinc
- Carba-nicotinamide-adenine-dinucleotide
- NU1025
- Nicotinamide
- 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
- 3-Methoxybenzamide
- 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
- 3,4-Dihydro-5-Methyl-Isoquinolinone
- 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide
- 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
- Veliparib
- A-620223
- 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
- Olaparib
- Talazoparib
- Niraparib
- Rucaparib
- Iniparib
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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POLA1
|
DNA polymerase alpha 1, catalytic subunit |
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Polymerase switching on the C-strand of the telomere
- Telomere C-strand synthesis initiation
- DNA replication initiation
- Activation of the pre-replicative complex
- Polymerase switching
- Removal of the Flap Intermediate
- Processive synthesis on the lagging strand
- G1/S-Specific Transcription
- Defective pyroptosis
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- Cladribine
- Clofarabine
- Fludarabine
- Nelarabine
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PRIM2
|
DNA primase subunit 2 |
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Polymerase switching on the C-strand of the telomere
- Telomere C-strand synthesis initiation
- DNA replication initiation
- Activation of the pre-replicative complex
- Polymerase switching
- Removal of the Flap Intermediate
- Processive synthesis on the lagging strand
- Defective pyroptosis
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PRPF38A
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pre-mRNA processing factor 38A |
- mRNA Splicing - Major Pathway
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RBM23
|
RNA binding motif protein 23 |
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SETDB1
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SET domain bifurcated histone lysine methyltransferase 1 |
- PKMTs methylate histone lysines
- Regulation of endogenous retroelements by KRAB-ZFP proteins
- Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
- Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
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SNU13
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small nuclear ribonucleoprotein 13 |
- rRNA modification in the nucleus and cytosol
- Major pathway of rRNA processing in the nucleolus and cytosol
- mRNA Splicing - Major Pathway
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- (S)-3-phenyllactic acid
- Anisomycin
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STK40
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serine/threonine kinase 40 |
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ULK2
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unc-51 like autophagy activating kinase 2 |
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