|
|
HAUS1 |
HAUS augmin like complex subunit 1 |
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- AURKA Activation by TPX2
|
|
|
|
|
JUNB |
JunB proto-oncogene, AP-1 transcription factor subunit |
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Interleukin-4 and Interleukin-13 signaling
- NGF-stimulated transcription
- NGF-stimulated transcription
- Nuclear events stimulated by ALK signaling in cancer
|
|
|
|
|
KANSL1 |
KAT8 regulatory NSL complex subunit 1 |
- HATs acetylate histones
- Formation of WDR5-containing histone-modifying complexes
|
|
|
|
|
KAT5 |
lysine acetyltransferase 5 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- DNA Damage/Telomere Stress Induced Senescence
- HATs acetylate histones
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Sensing of DNA Double Strand Breaks
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Estrogen-dependent gene expression
- Defective homologous recombination repair (HRR) due to BRCA1 loss of function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
- Impaired BRCA2 binding to RAD51
- Impaired BRCA2 binding to PALB2
- Cardiogenesis
|
- Coenzyme A
- S-Acetyl-Cysteine
|
|
|
|
KAT7 |
lysine acetyltransferase 7 |
|
|
|
|
|
KRT1 |
keratin 1 |
- Neutrophil degranulation
- Keratinization
- Formation of the cornified envelope
- Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
|
|
- Ichthyosis hystrix, Curth-Macklin type
- Epidermolytic palmoplantar keratoderma (EPPK)
- Striate palmoplantar keratoderma
- Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)
|
|
|
L3MBTL4 |
L3MBTL histone methyl-lysine binding protein 4 |
|
|
|
|
|
LRSAM1 |
leucine rich repeat and sterile alpha motif containing 1 |
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
|
LZTS2 |
leucine zipper tumor suppressor 2 |
|
|
|
|
|
MAD1L1 |
mitotic arrest deficient 1 like 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
|
|
|
|
|
MBIP |
MAP3K12 binding inhibitory protein 1 |
- HATs acetylate histones
- Formation of WDR5-containing histone-modifying complexes
|
|
|
|
|
MCM10 |
minichromosome maintenance 10 replication initiation factor |
- Activation of ATR in response to replication stress
- Activation of the pre-replicative complex
|
|
|
|
|
PLK1 |
polo like kinase 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Polo-like kinase mediated events
- Golgi Cisternae Pericentriolar Stack Reorganization
- Golgi Cisternae Pericentriolar Stack Reorganization
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Phosphorylation of the APC/C
- Phosphorylation of Emi1
- Condensation of Prophase Chromosomes
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Regulation of PLK1 Activity at G2/M Transition
- Activation of NIMA Kinases NEK9, NEK6, NEK7
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- Mitotic Metaphase/Anaphase Transition
- Mitotic Telophase/Cytokinesis
- Cyclin A/B1/B2 associated events during G2/M transition
- The role of GTSE1 in G2/M progression after G2 checkpoint
- AURKA Activation by TPX2
- EML4 and NUDC in mitotic spindle formation
- Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
|
- 3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
- 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
- 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
- 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
- Wortmannin
- Fostamatinib
- Volasertib
|
|
|
|
PRPF18 |
pre-mRNA processing factor 18 |
- mRNA Splicing - Major Pathway
|
|
|
|
|
PRPF3 |
pre-mRNA processing factor 3 |
- mRNA Splicing - Major Pathway
|
|
- Retinitis pigmentosa (RP)
|
|
|
RBM41 |
RNA binding motif protein 41 |
|
|
|
|
|
RCOR3 |
REST corepressor 3 |
|
|
|
|
|
RGS2 |
regulator of G protein signaling 2 |
- G alpha (q) signalling events
|
|
|
|
|
RIBC2 |
RIB43A domain with coiled-coils 2 |
|
|
|
|
|
RNF40 |
ring finger protein 40 |
- E3 ubiquitin ligases ubiquitinate target proteins
|
|
|