ECSIT - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CYP2C9	cytochrome P450 family 2 subfamily C member 9	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs Aspirin ADME	Ferroheme C Diacerein Benzbromarone
DNAJB1	DnaJ heat shock protein family (Hsp40) member B1	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling
DTX2	deltex E3 ubiquitin ligase 2	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
ELAVL3	ELAV like RNA binding protein 3
EXOC6	exocyst complex component 6	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
EXOSC1	exosome component 1	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
FARSA	phenylalanyl-tRNA synthetase subunit alpha	Cytosolic tRNA aminoacylation	Phenylalanine
FBXL12	F-box and leucine rich repeat protein 12	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
FBXW4	F-box and WD repeat domain containing 4	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
GCDH	glutaryl-CoA dehydrogenase	Lysine catabolism	Flavin adenine dinucleotide S-4-Nitrobutyryl-CoA	Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GEM	GTP binding protein overexpressed in skeletal muscle	NPAS4 regulates expression of target genes
IFIT3	interferon induced protein with tetratricopeptide repeats 3	Interferon alpha/beta signaling
IFIT5	interferon induced protein with tetratricopeptide repeats 5	Interferon alpha/beta signaling
IMMT	inner membrane mitochondrial protein	Cristae formation
LONP1	lon peptidase 1, mitochondrial	Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
LOXL4	lysyl oxidase like 4	Elastic fibre formation Crosslinking of collagen fibrils
MAGEB2	MAGE family member B2
MAST1	microtubule associated serine/threonine kinase 1		Fostamatinib
MKRN3	makorin ring finger protein 3
NFKB1	nuclear factor kappa B subunit 1	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Neutrophil degranulation The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation HCMV Early Events Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses Regulation of NFE2L2 gene expression Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription	Sulfasalazine Donepezil Pseudoephedrine Pranlukast Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Triflusal Terpinen-4-ol Glycyrrhizic acid Fish oil SC-236

Search Results for: ECSIT