TAB3 and MAP3K7CL

Number of citations: 0 (PubMedID 16189514)
Data Source: HPRD (two hybrid)

		TAB3	MAP3K7CL
Name		TGF-beta activated kinase 1 (MAP3K7) binding protein 3	MAP3K7 C-terminal like
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome	Nucleus Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Molecular Adaptor Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding
	Biological Process	Canonical NF-kappaB Signal Transduction Response To Bacterium Negative Regulation Of Autophagy Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction	None
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	None
GWAS		No GWAS studies recorded	Alanine aminotransferase levels ( 33547301 ) Coronary artery disease ( 29212778 33020668 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136 ) Gamma glutamyl transferase levels ( 29403010 33339817 ) Ventricular ectopy ( 29618737 ) White blood cell count ( 32888494 )
Interacting Genes		12 interacting genes: AMFR CEP57L1 IKBKG MAP3K7CL OGT PIN1 PPIL3 STAT3 TAB1 TRAF2 TRAF6 UBC	10 interacting genes: AK8 CISH CRYAA DDIT4L GPS2 KRT31 KRT34 REL TAB3 USF1
Entrez ID		257397	56911
HPRD ID		06738	10764
Ensembl ID		ENSG00000157625	ENSG00000156265
Uniprot IDs		Q8N5C8	B0EVZ6 B0EVZ7 B0EVZ8 B4DFW0 P57077
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Protein-containing Complex Signaling Adaptor Activity Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Autoubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-17-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process CD40 Receptor Complex Positive Regulation Of Signal Transduction Positive Regulation Of JUN Kinase Activity Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Gene Expression Negative Regulation Of Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Synapse Negative Regulation Of Signal Transduction Positive Regulation Of T Cell Cytokine Production Regulation Of Receptor Localization To Synapse Tumor Necrosis Factor Receptor Binding Regulation Of Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Peptidyl-prolyl Cis-trans Isomerase Activity Positive Regulation Of MAP Kinase Activity Cytosol Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Cytokine Production Protein Modification Process Protein-macromolecule Adaptor Activity Glutamatergic Synapse Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation	Structural Molecule Activity Non-canonical NF-kappaB Signal Transduction