MAP3K7CL and CISH

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MAP3K7CL	CISH
Description		MAP3K7 C-terminal like	cytokine inducible SH2 containing protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Cytokine Receptor Binding Protein Binding
	Biological Process		Regulation Of Cell Growth Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Pathways			Interleukin-7 signaling Neddylation Growth hormone receptor signaling
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Gamma glutamyl transferase levels ( 29403010 33339817) Ventricular ectopy ( 29618737) White blood cell count ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: AK8 CISH CRYAA DDIT4L GPS2 KRT31 KRT34 REL TAB3 USF1	20 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA JAK1 JAK2 JAK3 KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		56911	1154
HPRD ID		10764	03897
Ensembl ID		ENSG00000156265	ENSG00000114737
Uniprot IDs		B0EVZ6 B0EVZ7 B0EVZ8 B4DFW0 P57077	Q9NSE2
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Molecule Activity Non-canonical NF-kappaB Signal Transduction	Cytokine-mediated Signaling Pathway Cytokine Receptor Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytokine Binding Receptor Complex Growth Hormone Receptor Signaling Pathway Via JAK-STAT External Side Of Plasma Membrane Protein Phosphorylation Regulation Of Cell Population Proliferation Response To Cytokine Response To Peptide Signal Transduction Phosphorylation Growth Hormone Receptor Signaling Pathway Plasma Membrane Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Protein Kinase Activity Erythropoietin-mediated Signaling Pathway Extrinsic Component Of Plasma Membrane Interleukin-15-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-2-mediated Signaling Pathway Kinase Activity Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Diacylglycerol-dependent Serine/threonine Kinase Activity Adaptive Immune Response Interleukin-3 Receptor Activity Histone H3T6 Kinase Activity Regulation Of Receptor Signaling Pathway Via JAK-STAT Intracellular Signal Transduction Leukocyte Activation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-17 Production Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Platelet Aggregation Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway
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