SH2D3C and SNCAIP

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		SH2D3C	SNCAIP
Name		SH2 domain containing 3C	synuclein alpha interacting protein
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Ruffle Membrane Cell Projection	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	JNK Cascade Small GTPase-mediated Signal Transduction	Cell Death Dopamine Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly
Pathways		None	Amyloid fiber formation
GWAS		Basophil percentage of white cells ( 32888494 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of white cells ( 32888494 )	Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649 ) Delirium ( 29631748 ) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308 ) Heart rate increase in response to exercise ( 29497042 ) Heart rate response to recovery post exercise (50 sec) ( 29497042 ) Mood disorder and prion disease ( 25897833 ) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539 )
Interacting Genes		16 interacting genes: AR BCAR1 CARD11 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 KIT MAPK1 MET NEDD9 PTK2B SNCAIP SRC	19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB
Entrez ID		10044	9627
HPRD ID		05284	04804
Ensembl ID		ENSG00000095370	ENSG00000064692
Uniprot IDs		B4DG32 Q8N5H7	B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5
PDB IDs		3T6G	2KES
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity ERBB Signaling Pathway ERBB2 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Peptidyl-tyrosine Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Locomotion Positive Regulation Of Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cell Migration Basal Plasma Membrane Positive Regulation Of MAPK Cascade Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Protein Phosphorylation Receptor Complex Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphorylation Negative Regulation Of Programmed Cell Death Cell Migration Positive Regulation Of Metabolic Process Signal Transduction ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Focal Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling ATP Binding Plasma Membrane Response To Epidermal Growth Factor Cell Motility	Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Lewy Body Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Signaling Pathway Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Dopamine Transport Proteolysis Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Dopamine Secretion Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Stability Protein Ubiquitination Mitochondrial Outer Membrane Axon Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Monoamine Transport Protein Modification By Small Protein Conjugation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuron Apoptotic Process Response To Hydrogen Sulfide Regulation Of Apoptotic Process Proteasomal Protein Catabolic Process Regulation Of Programmed Cell Death Regulation Of Catecholamine Secretion Catabolic Process Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Regulation Of Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Tau Protein Binding Positive Regulation Of Protein Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Post-translational Protein Modification Regulation Of Wnt Signaling Pathway Protein Modification Process Cytosol Negative Regulation Of Wnt Signaling Pathway