IL27RA

Name	interleukin 27 receptor subunit alpha
Structure
Novel Interactors	1 novel interactors: GDF15
Interactors	11 interactors: CLDN2 DEFB121 DERL3 EBI3 GALNT15 IL27 MAPK8 SLC41A2 SLC61A1 STAT1 YIPF6
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Interleukin-27 Receptor Activity
	Biological Process	Negative Regulation Of Cellular Extravasation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Negative Regulation Of Neuron Apoptotic Process Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation
Pathways	Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
GWAS	Blood protein levels ( 30072576 ) Immune response to measles-mumps-rubella vaccine ( 24811271 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 )
Entrez ID	9466
HPRD ID	09247
Ensembl ID	ENSG00000104998
Uniprot IDs	Q6UWB1
PDB IDs	7T5M 7U7N 8D85
GO Terms Enriched among Interactors ?	Interleukin-27 Receptor Binding JUN Phosphorylation Response To Stress Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus By Host Response To Metformin Cytokine Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Response To External Biotic Stimulus Energy Homeostasis Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Intestinal D-glucose Absorption Positive Regulation Of Type II Interferon Production Nickel Cation Transport