TXNRD1

Name	thioredoxin reductase 1
Structure
Interactors	12 interactors: CEBPA DMRTC2 ESR1 ESR2 GLRX2 LINC01554 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Identical Protein Binding NADPH Peroxidase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Mesoderm Formation Signal Transduction Gastrulation Cell Population Proliferation Cell Redox Homeostasis Cellular Oxidant Detoxification
Pathways	PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs	Arsenic trioxide NADPH Flavin adenine dinucleotide Spermidine Fotemustine Motexafin gadolinium PX-12
GWAS	Blood protein levels ( 30072576 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Toenail selenium levels ( 25343990 )
Entrez ID	7296
HPRD ID	03068
Ensembl ID	ENSG00000198431
Uniprot IDs	B7Z2S5 Q16881
PDB IDs	2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB 7X1R
GO Terms Enriched among Interactors ?	Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Estrogen Receptor Activity Nuclear Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Estrogen Response Element Binding Nuclear Receptor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Response To Estradiol Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway TBP-class Protein Binding Steroid Binding Negative Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Estradiol Stimulus Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Transcription Cis-regulatory Region Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Arsenate Reductase (glutaredoxin) Activity Enzyme Inhibitor Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Vitamin B2 C/EBP Complex Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Female Courtship Behavior Glutathione Disulfide Oxidoreductase Activity Regulation Of DNA-templated Transcription Initiation