OCRL

Name	OCRL inositol polyphosphate-5-phosphatase
Structure
Novel Interactors	1 novel interactors: TYMS
Interactors	13 interactors: CDC42 CLTC GOLGA5 GRB2 LHX3 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1 TFAP2A
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Endosome Early Endosome Golgi Apparatus Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Cilium Microtubule Cytoskeleton Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Hydrolase Activity Phosphatase Activity Small GTPase Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity
	Biological Process	In Utero Embryonic Development Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Cell Projection Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Cilium Assembly Membrane Organization
Pathways	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis RHOJ GTPase cycle RAC3 GTPase cycle
Diseases	Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
GWAS	No GWAS studies recorded
Entrez ID	4952
HPRD ID	02395
Ensembl ID	ENSG00000122126
Uniprot IDs	A0A2X0TVZ9 Q01968 Q504W7
PDB IDs	2KIE 2QV2 3QBT 3QIS 4CMN
GO Terms Enriched among Interactors ?	GTPase Activity Vesicle-mediated Transport GTP Binding G Protein Activity Phagocytic Vesicle Endocytosis Intracellular Protein Transport Import Into Cell Receptor Internalization Trans-Golgi Network Myosin V Binding GDP Binding Cellular Localization Endosome Intracellular Transport Melanosome Intracellular Protein Localization Trans-Golgi Network Membrane Endosomal Transport Endomembrane System Cytoplasmic Vesicle Golgi Vesicle Transport Golgi Organization Extracellular Exosome Golgi Membrane Establishment Of Localization In Cell Protein Transport Receptor-mediated Endocytosis Hydrolase Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Amyloid-beta Clearance By Transcytosis Regulation Of Neuronal Synaptic Plasticity Early Endosome Membrane Nucleotide Binding Protein Kinase Binding Establishment Of Protein Localization Thioesterase Binding Plasma Membrane Bounded Cell Projection Organization Golgi Apparatus Phagocytic Vesicle Membrane Phagosome Maturation Organelle Transport Along Microtubule Localization Within Membrane Secretory Granule Membrane Retrograde Transport, Endosome To Golgi Recycling Endosome Membrane Trans-Golgi Network Transport Vesicle Early Endosome To Golgi Transport Protein Localization To Membrane Anatomical Structure Arrangement