NEU1

Name	neuraminidase 1
Structure	No pdb structure
Novel Interactors	8 novel interactors: CDC42SE2 IGF1 MAF MSH5 NFYA NOTCH4 PBX2 SLC17A2
Interactors	30 interactors: AQP6 CCR9 CD79A CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 JUNB KCNA2 KCNA4 LIG4 LMNA MGST3 MUC1 SLC10A1 SLC10A6 SLC18A1 SLC39A9 TMEM14B UBC
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cytoplasmic Vesicle Specific Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Exo-alpha-sialidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Alpha-sialidase Activity
	Biological Process	Lipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Lipid Catabolic Process
Pathways	Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism
Drugs	Oseltamivir Celecoxib Acetylsalicylic acid
Diseases	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Sialidosis; Mucolipidosis I Galactosialidosis
GWAS	A body shape index ( 34021172 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Basal cell carcinoma ( 27539887 ) Estimated glomerular filtration rate ( 31152163 ) Inflammatory bowel disease ( 28067908 ) Neutrophil percentage of white cells ( 32888494 ) Platelet distribution width ( 32888494 ) Small cell lung carcinoma ( 28604730 ) Squamous cell lung carcinoma ( 28604730 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 )
Entrez ID	4758
HPRD ID	09751
Ensembl ID	ENSG00000204386
Uniprot IDs	Q5JQI0 Q99519
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Membrane Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Integrated Stress Response Signaling Sphingosine N-acyltransferase Activity Regulation Of Chaperone-mediated Autophagy Lung Vasculature Development Negative Regulation Of Apoptotic Signaling Pathway Vasculature Development RNA Polymerase II Transcription Regulator Complex Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Type B Pancreatic Cell Proliferation Endoplasmic Reticulum Regulation Of Cardiac Muscle Hypertrophy