HLA-DMA

Name	major histocompatibility complex, class II, DM alpha
Structure
Interactors	8 interactors: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Cell Surface Membrane Late Endosome Membrane MHC Class II Protein Complex
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation
Pathways	MHC class II antigen presentation
Diseases	Allograft rejection
GWAS	Appendicular lean mass ( 33097823 ) Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Lymphocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 )
Entrez ID	3108
HPRD ID	00830
Ensembl ID	ENSG00000204257
Uniprot IDs	P28067 Q31604 Q6ICR9
PDB IDs	1HDM 2BC4 4FQX 4GBX 4I0P
GO Terms Enriched among Interactors ?	MHC Class II Protein Complex MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Peptide Antigen Binding MHC Class II Receptor Activity Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Endogenous Antigen Lysosomal Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Late Endosome Membrane Myeloid Dendritic Cell Antigen Processing And Presentation Lysosome Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Transport Vesicle Membrane Regulation Of Lymphocyte Differentiation Dendritic Cell Antigen Processing And Presentation ER To Golgi Transport Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Regulation Of Cell Activation Protein-containing Complex Assembly Positive Regulation Of Immune Effector Process Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Endocytic Vesicle Membrane Positive Regulation Of Immune Response Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Autolysosome Membrane CD4 Receptor Binding Positive Regulation Of Memory T Cell Differentiation Protein-containing Complex Organization Endosome Positive Regulation Of Monocyte Differentiation Regulation Of Cell Adhesion