ADH5

Name	alcohol dehydrogenase 5 (class III), chi polypeptide
Structure
Novel Interactors	1 novel interactors: KEAP1
Interactors	10 interactors: APP ARNT CHD3 CSNK2B ESRRA PRDX1 SLC66A2 SNTA1 USP40 VTN
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity Fatty Acid Binding Zinc Ion Binding Electron Transfer Activity Oxidoreductase Activity Formaldehyde Dehydrogenase (NAD+) Activity Identical Protein Binding Metal Ion Binding S-(hydroxymethyl)glutathione Dehydrogenase [NAD(P)+] Activity S-nitrosoglutathione Reductase (NADH) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NADP+) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NAD+) Activity
	Biological Process	Retinoid Metabolic Process Respiratory System Process Lipid Metabolic Process Fatty Acid Omega-oxidation Response To Lipopolysaccharide Small Molecule Metabolic Process Positive Regulation Of Blood Pressure Formaldehyde Catabolic Process Response To Nitrosative Stress Response To Redox State
Pathways	Ethanol oxidation
Drugs	NADH Lauric acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
GWAS	Alcohol consumption ( 28937693 ) Alcohol consumption in current drinkers ( 28937693 ) Alcohol dependence ( 23456092 ) Blood protein levels ( 30072576 ) HDL cholesterol ( 24097068 25961943 ) HDL cholesterol levels ( 28334899 ) Obesity-related traits ( 23251661 ) Plateletcrit ( 32888494 ) Regular attendance at a pub or social club ( 29970889 )
Entrez ID	128
HPRD ID	00064
Ensembl ID	ENSG00000197894
Uniprot IDs	P11766 Q6IRT1
PDB IDs	1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5 8GV3
GO Terms Enriched among Interactors ?	Regulation Of Proteolysis Positive Regulation Of Glycolytic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of ATP Metabolic Process Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Nuclear Receptor Activity Symbiont-containing Vacuole Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Golgi Lumen Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Catabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Nuclear Aryl Hydrocarbon Receptor Complex Response To Oxidative Stress Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Smooth Muscle Cell-matrix Adhesion Rough Endoplasmic Reticulum Lumen Alphav-beta3 Integrin-vitronectin Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Norepinephrine Stimulus Negative Regulation Of Macromolecule Metabolic Process Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling PML Body Syntrophin Complex