FRS2

Name	fibroblast growth factor receptor substrate 2
Structure
Interactors	28 interactors: BECN1 CBL CDK3 CRK DDR1 FGFR1 GAB1 GRB2 INSR KDR MAPK1 MAPK3 NCK1 NTRK1 NTRK2 NTRK3 PAK1 PIN1 PRKCI PRKCZ PTPN11 PTPRF RET RND1 RPS6 SOS1 SRC YJU2
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Endomembrane System Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phosphatase Activator Activity
	Biological Process	Gastrulation With Mouth Forming Second Organ Induction Lens Development In Camera-type Eye Ventricular Septum Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuroblast Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Lens Placode Formation Involved In Camera-type Eye Formation Regulation Of Epithelial Cell Proliferation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways	PI3K Cascade PIP3 activates AKT signaling Frs2-mediated activation Frs2-mediated activation Signaling by ALK Constitutive Signaling by Aberrant PI3K in Cancer PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants
GWAS	Complete remission in asthma ( 29786918 ) Heel bone mineral density ( 30598549 ) Height ( 18391951 20881960 23563607 25282103 25429064 31562340 ) Hip circumference adjusted for BMI ( 25673412 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Microalbuminuria ( 31511532 ) Response to antidepressants (symptom remission) ( 29160301 ) Response to diuretic therapy ( 18591461 ) Thyroid stimulating hormone levels ( 32769997 ) Urinary albumin-to-creatinine ratio ( 31511532 )
Entrez ID	10818
HPRD ID	06372
Ensembl ID	ENSG00000166225
Uniprot IDs	L7RTG7 Q8WU20
PDB IDs	1XR0 2MFQ
GO Terms Enriched among Interactors ?	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Tyrosine Kinase Activity Cell Migration Ephrin Receptor Signaling Pathway Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Cell Motility Protein Autophosphorylation ERBB Signaling Pathway Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Phosphotyrosine Residue Binding Positive Regulation Of Cell Projection Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Peptidyl-tyrosine Phosphorylation Regulation Of Cell Projection Organization Cell Development Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration ATP Binding Receptor Complex Ephrin Receptor Binding Positive Regulation Of Cell Motility Neurotrophin Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Locomotion