HSP90B1 and POLR2E |
heat shock protein 90kDa beta (Grp94), member 1 |
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa |
- Toll-Like Receptors Cascades
- Trafficking and processing of endosomal TLR
- Scavenging by Class A Receptors
- ATF6-alpha activates chaperones
- ATF6-alpha activates chaperone genes
- Unfolded Protein Response (UPR)
- Innate Immune System
|
- RNA Polymerase II Promoter Escape
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Chain Elongation
- Abortive elongation of HIV-1 transcript in the absence of Tat
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Regulatory RNA pathways
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- Formation of transcription-coupled NER (TC-NER) repair complex
- Dual incision reaction in TC-NER
- Influenza Life Cycle
- RNA Polymerase III Transcription Termination
- HIV elongation arrest and recovery
- NoRC negatively regulates rRNA expression
- Influenza Viral RNA Transcription and Replication
- RNA Polymerase III Chain Elongation
- RNA Polymerase III Transcription
- RNA Polymerase III Transcription Initiation From Type 1 Promoter
- mRNA Splicing - Minor Pathway
- mRNA Splicing - Major Pathway
- MicroRNA (miRNA) biogenesis
- Influenza Infection
- Pausing and recovery of Tat-mediated HIV elongation
- Late Phase of HIV Life Cycle
- RNA Polymerase III Transcription Initiation From Type 2 Promoter
- Formation of RNA Pol II elongation complex
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- RNA Polymerase III Abortive And Retractive Initiation
- Transcription of the HIV genome
- Nucleotide Excision Repair
- PIWI-interacting RNA (piRNA) biogenesis
- mRNA Splicing
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
- RNA Polymerase II Transcription
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Promoter Clearance
- HIV Infection
- Formation of the Early Elongation Complex
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- HIV Transcription Initiation
- HIV Life Cycle
- RNA Pol II CTD phosphorylation and interaction with CE
- Transcriptional regulation of pluripotent stem cells
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Innate Immune System
- RNA Polymerase III Transcription Initiation
- Transcriptional regulation by small RNAs
- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Capping
- RNA Polymerase I Transcription
- RNA Polymerase I Promoter Escape
- RNA Polymerase I Transcription Termination
- Cytosolic sensors of pathogen-associated DNA
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Transcription-coupled NER (TC-NER)
- Formation of HIV elongation complex in the absence of HIV Tat
- Pausing and recovery of HIV elongation
- Formation of the HIV-1 Early Elongation Complex
- Viral Messenger RNA Synthesis
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Elongation
|
- Rifabutin
- 2-Chlorodideoxyadenosine
- 1-Methoxy-2-(2-Methoxyethoxy)Ethane
- Adenosine-5\'-Diphosphate
- N-Ethyl-5\'-Carboxamido Adenosine
- Radicicol
- METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE
- 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
|
|
|
|
TNNC1 and POLR2G |
troponin C type 1 (slow) |
polymerase (RNA) II (DNA directed) polypeptide G |
- Striated Muscle Contraction
|
- RNA Polymerase II Promoter Escape
- mRNA Splicing
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- PIWI-interacting RNA (piRNA) biogenesis
- Nucleotide Excision Repair
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Regulatory RNA pathways
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- Formation of transcription-coupled NER (TC-NER) repair complex
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- Dual incision reaction in TC-NER
- Influenza Life Cycle
- HIV elongation arrest and recovery
- HIV Life Cycle
- HIV Transcription Initiation
- Influenza Viral RNA Transcription and Replication
- RNA Pol II CTD phosphorylation and interaction with CE
- Transcriptional regulation of pluripotent stem cells
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Transcriptional regulation by small RNAs
- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Capping
- mRNA Splicing - Minor Pathway
- mRNA Splicing - Major Pathway
- MicroRNA (miRNA) biogenesis
- Influenza Infection
- Pausing and recovery of Tat-mediated HIV elongation
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Transcription-coupled NER (TC-NER)
- Viral Messenger RNA Synthesis
- Formation of the HIV-1 Early Elongation Complex
- RNA Polymerase II Transcription Initiation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
|
- Trifluoperazine
- Levosimendan
- Felodipine
- Bepridil
- Calcium
- Dihydroxyaluminium
- 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One
- N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
|
|
|
|
GRIA1 and CANX |
glutamate receptor, ionotropic, AMPA 1 |
calnexin |
- Trafficking of GluR2-containing AMPA receptors
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Activation of AMPA receptors
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- Trafficking of AMPA receptors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Transmission across Chemical Synapses
|
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- L-Glutamic Acid
- Enflurane
- Isoflurane
- Methoxyflurane
- Desflurane
- Sevoflurane
- Perampanel
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
BLVRB and RPL31 |
biliverdin reductase B |
ribosomal protein L31 |
- Metabolism of porphyrins
- Heme degradation
|
- Nonsense-Mediated Decay (NMD)
- Translation
- SRP-dependent cotranslational protein targeting to membrane
- Eukaryotic Translation Termination
- Peptide chain elongation
- Influenza Infection
- Viral mRNA Translation
- L13a-mediated translational silencing of Ceruloplasmin expression
- Influenza Life Cycle
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Influenza Viral RNA Transcription and Replication
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Initiation
- Formation of a pool of free 40S subunits
- Eukaryotic Translation Elongation
- Cap-dependent Translation Initiation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
|
- Riboflavin
- NADH
- Biliverdine Ix Alpha
- Riboflavin Monophosphate
- 2\'-Monophosphoadenosine 5\'-Diphosphoribose
- 7,8-dimethylalloxazine
- Mesobiliverdin Iv Alpha
|
|
|
|
CDK5 and RPL34 |
cyclin-dependent kinase 5 |
ribosomal protein L34 |
- Signaling by GPCR
- Axon guidance
- Semaphorin interactions
- Opioid Signalling
- DARPP-32 events
- CRMPs in Sema3A signaling
- Factors involved in megakaryocyte development and platelet production
|
- Nonsense-Mediated Decay (NMD)
- Translation
- SRP-dependent cotranslational protein targeting to membrane
- Eukaryotic Translation Termination
- Peptide chain elongation
- Influenza Infection
- Viral mRNA Translation
- L13a-mediated translational silencing of Ceruloplasmin expression
- Influenza Life Cycle
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Influenza Viral RNA Transcription and Replication
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Initiation
- Formation of a pool of free 40S subunits
- Eukaryotic Translation Elongation
- Cap-dependent Translation Initiation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
|
- Indirubin-3\'-Monoxime
- Olomoucine
- Hymenialdisine
- SU9516
- Flavopiridol
- Alsterpaullone
- 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
|
|
|
|
PDGFRB and EIF2AK2 |
platelet-derived growth factor receptor, beta polypeptide |
eukaryotic translation initiation factor 2-alpha kinase 2 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- PIP3 activates AKT signaling
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Innate Immune System
- Signaling by PDGF
- Signalling by NGF
- DAP12 interactions
- GAB1 signalosome
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by FGFR
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
|
- ISG15 antiviral mechanism
- Interferon Signaling
- Inhibition of PKR
- Cytokine Signaling in Immune system
- Host Interactions with Influenza Factors
- Influenza Infection
- NS1 Mediated Effects on Host Pathways
- Antiviral mechanism by IFN-stimulated genes
|
- Becaplermin
- Sorafenib
- Imatinib
- Dasatinib
- Sunitinib
- Pazopanib
- Regorafenib
|
|
|
|
LHCGR and CANX |
luteinizing hormone/choriogonadotropin receptor |
calnexin |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- G alpha (s) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Hormone ligand-binding receptors
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Goserelin
- Menotropins
- Lutropin alfa
- Cetrorelix
- Choriogonadotropin alfa
- Buserelin
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
ALDH2 and RPL13A |
aldehyde dehydrogenase 2 family (mitochondrial) |
ribosomal protein L13a |
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
- Metabolic disorders of biological oxidation enzymes
- Ethanol oxidation
- Phase 1 - Functionalization of compounds
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
- Biological oxidations
- Serotonin clearance from the synaptic cleft
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
- Defective FMO3 causes Trimethylaminuria (TMAU)
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
- Metabolism of serotonin
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
- Defective CYP1B1 causes Glaucoma
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
- Neurotransmitter Clearance In The Synaptic Cleft
- Defective MAOA causes Brunner syndrome (BRUNS)
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
- Transmission across Chemical Synapses
|
- Nonsense-Mediated Decay (NMD)
- Translation
- SRP-dependent cotranslational protein targeting to membrane
- Eukaryotic Translation Termination
- Peptide chain elongation
- Influenza Infection
- Viral mRNA Translation
- L13a-mediated translational silencing of Ceruloplasmin expression
- Influenza Life Cycle
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Influenza Viral RNA Transcription and Replication
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Initiation
- Formation of a pool of free 40S subunits
- Eukaryotic Translation Elongation
- Cap-dependent Translation Initiation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
|
- NADH
- Guanidine
- Disulfiram
- Nicotinamide-Adenine-Dinucleotide
- Daidzin
- Crotonaldehyde
|
|
|
|
PLAT and CALR |
plasminogen activator, tissue |
calreticulin |
- Signaling by PDGF
- Dissolution of Fibrin Clot
- Orphan transporters
|
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- Scavenging by Class F Receptors
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Scavenging by Class A Receptors
- Assembly of Viral Components at the Budding Site
- ATF6-alpha activates chaperones
- Unfolded Protein Response (UPR)
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- ATF6-alpha activates chaperone genes
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Urokinase
- Aminocaproic Acid
- Ibuprofen
- Iloprost
- 6-Amino Hexanoic Acid
- 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID
|
|
|
|
CDK1 and NUP210 |
cyclin-dependent kinase 1 |
nucleoporin 210kDa |
- Phosphorylation of the APC/C
- Signaling by FGFR in disease
- Phosphorylation of Emi1
- Signaling by EGFRvIII in Cancer
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- SOS-mediated signalling
- Mitotic G1-G1/S phases
- SHC-mediated signalling
- Recruitment of mitotic centrosome proteins and complexes
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- Nuclear Pore Complex (NPC) Disassembly
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- ERK1 activation
- APC/C:Cdc20 mediated degradation of Cyclin B
- Signaling by VEGF
- Resolution of Sister Chromatid Cohesion
- Downstream signal transduction
- Signalling to RAS
- Toll Like Receptor 3 (TLR3) Cascade
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- Interleukin-2 signaling
- Mitotic G2-G2/M phases
- Frs2-mediated activation
- MASTL Facilitates Mitotic Progression
- Axon guidance
- IRS-mediated signalling
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- Cyclin A/B1 associated events during G2/M transition
- Loss of Nlp from mitotic centrosomes
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Condensation of Prometaphase Chromosomes
- Signaling by Insulin receptor
- E2F mediated regulation of DNA replication
- Insulin receptor signalling cascade
- Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
- G0 and Early G1
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- E2F-enabled inhibition of pre-replication complex formation
- Regulation of mitotic cell cycle
- Cell Cycle Checkpoints
- Signaling by GPCR
- G2/M Checkpoints
- Mitotic Prophase
- Golgi Cisternae Pericentriolar Stack Reorganization
- FCERI mediated MAPK activation
- Regulation of PLK1 Activity at G2/M Transition
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- G1/S Transition
- G1/S-Specific Transcription
- Toll Like Receptor 9 (TLR9) Cascade
- G2/M DNA replication checkpoint
- Signaling by PDGF
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Condensation of Prophase Chromosomes
- Signaling by Leptin
- Signalling to ERKs
- Mitotic Prometaphase
- Prolonged ERK activation events
- Organelle biogenesis and maintenance
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Activation of NIMA Kinases NEK9, NEK6, NEK7
- Nuclear Envelope Breakdown
- IGF1R signaling cascade
- Recruitment of NuMA to mitotic centrosomes
- Cyclin B2 mediated events
- Toll Like Receptor TLR6:TLR2 Cascade
- M Phase
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- ERK activation
- Downstream signaling of activated FGFR
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Signalling by NGF
- SOS-mediated signalling
- G2/M DNA damage checkpoint
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Depolymerisation of the Nuclear Lamina
- Assembly of the primary cilium
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- SHC1 events in EGFR signaling
- Loss of proteins required for interphase microtubule organization from the centrosome
- FRS2-mediated cascade
- IRS-mediated signalling
- Centrosome maturation
|
- Mitotic Prophase
- HIV Infection
- Nuclear import of Rev protein
- Regulatory RNA pathways
- Rev-mediated nuclear export of HIV RNA
- Nuclear Envelope Breakdown
- SLC-mediated transmembrane transport
- M Phase
- Influenza Life Cycle
- HIV Life Cycle
- Influenza Viral RNA Transcription and Replication
- Rev-mediated nuclear export of HIV RNA
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- Transcriptional regulation by small RNAs
- Vpr-mediated nuclear import of PICs
- ISG15 antiviral mechanism
- Interferon Signaling
- Host Interactions of HIV factors
- Nuclear Pore Complex (NPC) Disassembly
- Regulation of Glucokinase by Glucokinase Regulatory Protein
- Cytokine Signaling in Immune system
- Interactions of Vpr with host cellular proteins
- Interactions of Rev with host cellular proteins
- Influenza Infection
- Hexose transport
- Cell Cycle, Mitotic
- Late Phase of HIV Life Cycle
- Antiviral mechanism by IFN-stimulated genes
- Viral Messenger RNA Synthesis
- Metabolism of carbohydrates
- Glucose transport
|
- Indirubin-3\'-Monoxime
- Olomoucine
- Hymenialdisine
- SU9516
- Flavopiridol
- Alsterpaullone
|
|
|
|
FGF2 and RPS19 |
fibroblast growth factor 2 (basic) |
ribosomal protein S19 |
- Signaling by the B Cell Receptor (BCR)
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- SHC-mediated cascade
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Signaling by FGFR2 mutants
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- Signaling by activated point mutants of FGFR1
- Signaling by FGFR1 mutants
- PI3K Cascade
- Negative regulation of FGFR signaling
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- Activated point mutants of FGFR2
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- FGFR4 ligand binding and activation
- Syndecan interactions
- Signaling by EGFR
- Signaling by FGFR3 mutants
- Downstream signal transduction
- Signaling by activated point mutants of FGFR3
- Fc epsilon receptor (FCERI) signaling
- Signaling by FGFR mutants
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- Transcriptional regulation of pluripotent stem cells
- PI3K events in ERBB2 signaling
- FGFR1b ligand binding and activation
- Downstream signaling of activated FGFR
- FGFR3c ligand binding and activation
- FGFR1c ligand binding and activation
- FGFR2c ligand binding and activation
- FGFR ligand binding and activation
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Insulin receptor signalling cascade
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Non-integrin membrane-ECM interactions
- FGFR3 ligand binding and activation
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- FGFR2 ligand binding and activation
- FRS2-mediated cascade
- IRS-mediated signalling
- FGFR1 ligand binding and activation
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- PI3K Cascade
|
- Nonsense-Mediated Decay (NMD)
- Translation initiation complex formation
- Translation
- SRP-dependent cotranslational protein targeting to membrane
- Eukaryotic Translation Termination
- Peptide chain elongation
- Influenza Infection
- Viral mRNA Translation
- L13a-mediated translational silencing of Ceruloplasmin expression
- Influenza Life Cycle
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Ribosomal scanning and start codon recognition
- Formation of the ternary complex, and subsequently, the 43S complex
- Influenza Viral RNA Transcription and Replication
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Initiation
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
- Formation of a pool of free 40S subunits
- Eukaryotic Translation Elongation
- Cap-dependent Translation Initiation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
|
- Sucralfate
- Pentosan Polysulfate
- Sirolimus
- 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
- N,O6-Disulfo-Glucosamine
- 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
|
|
|
|
FGF2 and RPL6 |
fibroblast growth factor 2 (basic) |
ribosomal protein L6 |
- Signaling by the B Cell Receptor (BCR)
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- SHC-mediated cascade
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Signaling by FGFR2 mutants
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- Signaling by activated point mutants of FGFR1
- Signaling by FGFR1 mutants
- PI3K Cascade
- Negative regulation of FGFR signaling
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- Activated point mutants of FGFR2
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- FGFR4 ligand binding and activation
- Syndecan interactions
- Signaling by EGFR
- Signaling by FGFR3 mutants
- Downstream signal transduction
- Signaling by activated point mutants of FGFR3
- Fc epsilon receptor (FCERI) signaling
- Signaling by FGFR mutants
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- Transcriptional regulation of pluripotent stem cells
- PI3K events in ERBB2 signaling
- FGFR1b ligand binding and activation
- Downstream signaling of activated FGFR
- FGFR3c ligand binding and activation
- FGFR1c ligand binding and activation
- FGFR2c ligand binding and activation
- FGFR ligand binding and activation
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Insulin receptor signalling cascade
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Non-integrin membrane-ECM interactions
- FGFR3 ligand binding and activation
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- FGFR2 ligand binding and activation
- FRS2-mediated cascade
- IRS-mediated signalling
- FGFR1 ligand binding and activation
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- PI3K Cascade
|
- Nonsense-Mediated Decay (NMD)
- Translation
- SRP-dependent cotranslational protein targeting to membrane
- Eukaryotic Translation Termination
- Peptide chain elongation
- Influenza Infection
- Viral mRNA Translation
- L13a-mediated translational silencing of Ceruloplasmin expression
- Influenza Life Cycle
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Influenza Viral RNA Transcription and Replication
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Initiation
- Formation of a pool of free 40S subunits
- Eukaryotic Translation Elongation
- Cap-dependent Translation Initiation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
|
- Sucralfate
- Pentosan Polysulfate
- Sirolimus
- 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
- N,O6-Disulfo-Glucosamine
- 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
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|
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|
TUBA1A and KPNB1 |
tubulin, alpha 1a |
karyopherin (importin) beta 1 |
- Transport of connexons to the plasma membrane
- Mitotic Prometaphase
- Organelle biogenesis and maintenance
- Axon guidance
- Hedgehog 'off' state
- Separation of Sister Chromatids
- Translocation of GLUT4 to the plasma membrane
- L1CAM interactions
- G2/M Transition
- Mitotic Anaphase
- Recycling pathway of L1
- Recruitment of NuMA to mitotic centrosomes
- Regulation of PLK1 Activity at G2/M Transition
- Formation of tubulin folding intermediates by CCT/TriC
- Intraflagellar transport
- M Phase
- Prefoldin mediated transfer of substrate to CCT/TriC
- Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
- Post-chaperonin tubulin folding pathway
- Loss of Nlp from mitotic centrosomes
- Gap junction trafficking and regulation
- MHC class II antigen presentation
- Recruitment of mitotic centrosome proteins and complexes
- Protein folding
- Gap junction assembly
- Gap junction trafficking
- Kinesins
- Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
- Assembly of the primary cilium
- Factors involved in megakaryocyte development and platelet production
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Loss of proteins required for interphase microtubule organization from the centrosome
- Resolution of Sister Chromatid Cohesion
- Chaperonin-mediated protein folding
- Signaling by Hedgehog
- Centrosome maturation
- Mitotic G2-G2/M phases
- Mitotic Metaphase and Anaphase
- Adaptive Immune System
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- Metabolism of lipids and lipoproteins
- ISG15 antiviral mechanism
- Nuclear import of Rev protein
- HIV Infection
- Interferon Signaling
- Apoptotic execution phase
- Host Interactions of HIV factors
- Cytokine Signaling in Immune system
- Interactions of Rev with host cellular proteins
- Influenza Infection
- Antiviral mechanism by IFN-stimulated genes
- Influenza Life Cycle
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Activation of DNA fragmentation factor
- Transport of Ribonucleoproteins into the Host Nucleus
- Apoptosis induced DNA fragmentation
- Programmed Cell Death
|
- Albendazole
- Vinblastine
- Mebendazole
- Epothilone D
- Epothilone B
- 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
|
|
|
|
SYK and RPS10 |
spleen tyrosine kinase |
ribosomal protein S10 |
- Signaling by the B Cell Receptor (BCR)
- FCERI mediated MAPK activation
- Platelet Aggregation (Plug Formation)
- DAP12 signaling
- Regulation of signaling by CBL
- Role of phospholipids in phagocytosis
- Fcgamma receptor (FCGR) dependent phagocytosis
- FCGR activation
- Regulation of actin dynamics for phagocytic cup formation
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- DAP12 interactions
- Integrin alphaIIb beta3 signaling
- Cytokine Signaling in Immune system
- Role of LAT2/NTAL/LAB on calcium mobilization
- Signaling by Interleukins
- Fc epsilon receptor (FCERI) signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- FCERI mediated Ca+2 mobilization
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
|
- Nonsense-Mediated Decay (NMD)
- Translation initiation complex formation
- Translation
- SRP-dependent cotranslational protein targeting to membrane
- Eukaryotic Translation Termination
- Peptide chain elongation
- Influenza Infection
- Viral mRNA Translation
- L13a-mediated translational silencing of Ceruloplasmin expression
- Influenza Life Cycle
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Ribosomal scanning and start codon recognition
- Formation of the ternary complex, and subsequently, the 43S complex
- Influenza Viral RNA Transcription and Replication
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Initiation
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
- Formation of a pool of free 40S subunits
- Eukaryotic Translation Elongation
- Cap-dependent Translation Initiation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
|
- Staurosporine
- N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide
- 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
- 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
- 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
- Ellagic Acid
|
|
|
|
FSHR and CANX |
follicle stimulating hormone receptor |
calnexin |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- G alpha (s) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Hormone ligand-binding receptors
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Menotropins
- Follitropin beta
- Urofollitropin
- Choriogonadotropin alfa
- Suramin
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
FSHR and UBA52 |
follicle stimulating hormone receptor |
ubiquitin A-52 residue ribosomal protein fusion product 1 |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- G alpha (s) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Hormone ligand-binding receptors
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Hedgehog 'off' state
- Signaling by FGFR in disease
- Influenza Life Cycle
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Influenza Infection
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- APC truncation mutants have impaired AXIN binding
- HIV Infection
- Peptide chain elongation
- Assembly of the pre-replicative complex
- Activated TLR4 signalling
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- regulation of FZD by ubiquitination
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- p53-Independent G1/S DNA damage checkpoint
- Membrane binding and targetting of GAG proteins
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- Eukaryotic Translation Termination
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- Cell Cycle Checkpoints
- degradation of DVL
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Generic Transcription Pathway
- Regulation of the Fanconi anemia pathway
- G1/S Transition
- FBXW7 Mutants and NOTCH1 in Cancer
- Toll Like Receptor 9 (TLR9) Cascade
- IRAK1 recruits IKK complex
- truncations of AMER1 destabilize the destruction complex
- Negative regulation of FGFR signaling
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Translation
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Host Interactions of HIV factors
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Fc epsilon receptor (FCERI) signaling
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- APC truncation mutants are not K63 polyubiquitinated
- M Phase
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Viral mRNA Translation
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- Formation of a pool of free 40S subunits
- TRAF6 mediated induction of TAK1 complex
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- Cellular Senescence
- T41 mutants of beta-catenin aren't phosphorylated
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Downstream signaling events of B Cell Receptor (BCR)
- Assembly Of The HIV Virion
- Degradation of beta-catenin by the destruction complex
- Influenza Viral RNA Transcription and Replication
- NOD1/2 Signaling Pathway
- MyD88 dependent cascade initiated on endosome
- Glycogen storage diseases
- Cap-dependent Translation Initiation
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- Regulation of APC/C activators between G1/S and early anaphase
- L13a-mediated translational silencing of Ceruloplasmin expression
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- Interleukin-1 signaling
- Eukaryotic Translation Elongation
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- Oncogene Induced Senescence
- TGFBR1 LBD Mutants in Cancer
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- Eukaryotic Translation Initiation
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- Disease
- XAV939 inhibits tankyrase, stabilizing AXIN
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Nonsense-Mediated Decay (NMD)
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- Toll-Like Receptors Cascades
- NOTCH1 Intracellular Domain Regulates Transcription
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- SRP-dependent cotranslational protein targeting to membrane
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Signaling by ERBB2
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by EGFR in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- FBXW7 Mutants and NOTCH1 in Cancer
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Menotropins
- Follitropin beta
- Urofollitropin
- Choriogonadotropin alfa
- Suramin
|
|
|
|
FSHR and RPS27A |
follicle stimulating hormone receptor |
ribosomal protein S27a |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- G alpha (s) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Hormone ligand-binding receptors
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Hedgehog 'off' state
- Signaling by FGFR in disease
- Influenza Life Cycle
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Formation of the ternary complex, and subsequently, the 43S complex
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Influenza Infection
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- APC truncation mutants have impaired AXIN binding
- HIV Infection
- Peptide chain elongation
- Assembly of the pre-replicative complex
- Activated TLR4 signalling
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- regulation of FZD by ubiquitination
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- p53-Independent G1/S DNA damage checkpoint
- Membrane binding and targetting of GAG proteins
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- Eukaryotic Translation Termination
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- Cell Cycle Checkpoints
- degradation of DVL
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Translation initiation complex formation
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Generic Transcription Pathway
- Regulation of the Fanconi anemia pathway
- G1/S Transition
- FBXW7 Mutants and NOTCH1 in Cancer
- Toll Like Receptor 9 (TLR9) Cascade
- IRAK1 recruits IKK complex
- truncations of AMER1 destabilize the destruction complex
- Negative regulation of FGFR signaling
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Translation
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Host Interactions of HIV factors
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Fc epsilon receptor (FCERI) signaling
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- APC truncation mutants are not K63 polyubiquitinated
- M Phase
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Viral mRNA Translation
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- Formation of a pool of free 40S subunits
- TRAF6 mediated induction of TAK1 complex
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- Cellular Senescence
- T41 mutants of beta-catenin aren't phosphorylated
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Downstream signaling events of B Cell Receptor (BCR)
- Assembly Of The HIV Virion
- Degradation of beta-catenin by the destruction complex
- Influenza Viral RNA Transcription and Replication
- NOD1/2 Signaling Pathway
- MyD88 dependent cascade initiated on endosome
- Glycogen storage diseases
- Cap-dependent Translation Initiation
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- Regulation of APC/C activators between G1/S and early anaphase
- L13a-mediated translational silencing of Ceruloplasmin expression
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- Interleukin-1 signaling
- Eukaryotic Translation Elongation
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- Oncogene Induced Senescence
- TGFBR1 LBD Mutants in Cancer
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- Eukaryotic Translation Initiation
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- Disease
- XAV939 inhibits tankyrase, stabilizing AXIN
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Nonsense-Mediated Decay (NMD)
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- Toll-Like Receptors Cascades
- NOTCH1 Intracellular Domain Regulates Transcription
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- SRP-dependent cotranslational protein targeting to membrane
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Signaling by ERBB2
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by EGFR in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- FBXW7 Mutants and NOTCH1 in Cancer
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- Ribosomal scanning and start codon recognition
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
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- Menotropins
- Follitropin beta
- Urofollitropin
- Choriogonadotropin alfa
- Suramin
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BCL2 and HSPA1A |
B-cell CLL/lymphoma 2 |
heat shock 70kDa protein 1A |
- Activation of BAD and translocation to mitochondria
- Inflammasomes
- The NLRP1 inflammasome
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Programmed Cell Death
- Activation of BH3-only proteins
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Innate Immune System
- Intrinsic Pathway for Apoptosis
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- Regulation of mRNA stability by proteins that bind AU-rich elements
- Viral RNP Complexes in the Host Cell Nucleus
- Attenuation phase
- Regulation of HSF1-mediated heat shock response
- Cellular response to heat stress
- AUF1 (hnRNP D0) destabilizes mRNA
- Influenza Infection
- Influenza Life Cycle
- HSF1-dependent transactivation
- Export of Viral Ribonucleoproteins from Nucleus
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- Ibuprofen
- Paclitaxel
- Docetaxel
- Rasagiline
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CACNA1A and RPL31 |
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit |
ribosomal protein L31 |
- Integration of energy metabolism
- Regulation of insulin secretion
- Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
- Transmission across Chemical Synapses
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- Nonsense-Mediated Decay (NMD)
- Translation
- SRP-dependent cotranslational protein targeting to membrane
- Eukaryotic Translation Termination
- Peptide chain elongation
- Influenza Infection
- Viral mRNA Translation
- L13a-mediated translational silencing of Ceruloplasmin expression
- Influenza Life Cycle
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Influenza Viral RNA Transcription and Replication
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Initiation
- Formation of a pool of free 40S subunits
- Eukaryotic Translation Elongation
- Cap-dependent Translation Initiation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
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- Pregabalin
- Verapamil
- Loperamide
- Bepridil
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CACNA1A and RPS17 |
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit |
ribosomal protein S17 |
- Integration of energy metabolism
- Regulation of insulin secretion
- Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
- Transmission across Chemical Synapses
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- Nonsense-Mediated Decay (NMD)
- Translation initiation complex formation
- Translation
- SRP-dependent cotranslational protein targeting to membrane
- Eukaryotic Translation Termination
- Peptide chain elongation
- Influenza Infection
- Viral mRNA Translation
- L13a-mediated translational silencing of Ceruloplasmin expression
- Influenza Life Cycle
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Ribosomal scanning and start codon recognition
- Formation of the ternary complex, and subsequently, the 43S complex
- Influenza Viral RNA Transcription and Replication
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Initiation
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
- Formation of a pool of free 40S subunits
- Eukaryotic Translation Elongation
- Cap-dependent Translation Initiation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
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- Pregabalin
- Verapamil
- Loperamide
- Bepridil
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